5-aminolevulinic acid (ALA)-mediated photodynamic therapy for superficial skin tumors using Super Lizer

Hirata, Yui; Kiyohara, Tadahiko; Higashi, Koichiro; Iki, Mariko; Moriwaki, Shinichi; Kiyokane, Kimihiro

doi:10.5227/skincancer.22.120

Cited by 1 publication

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“…Another report stated that progression was noted in 8% of patients . Surgery is the first‐line treatment for AK; however, when a patient has recurrent or multiple episodes of AK or requests treatment other than surgery, various therapies are available, including CO 2 laser treatment, cryotherapy, topical treatment with 5‐fluorouracil (5‐FU), imiquimod, and diclofenac, skin abrasion, chemical peeling and photodynamic therapy (PDT) . Because imiquimod is a topical medication, it has advantages in that it is convenient and safe to use and that there is no need to limit the facilities that can provide imiquimod treatment.…”

Section: Discussionmentioning

confidence: 99%

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Association between the clinical and histopathological classifications of actinic keratosis and the efficacy of topical imiquimod treatment

Tanizaki

Kokunai

et al. 2017

The Journal of Dermatology

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We investigated the association between the clinical and histopathological classifications of actinic keratosis (AK) and the efficacy of topical imiquimod treatment. Forty patients (55 lesions) with AK were treated with topical 5% imiquimod and the efficacy of imiquimod for AK was evaluated based on the clinical/histopathological changes. The complete remission (CR) rates in patients with the different clinical classifications of AK were 85.4% (erythematous type) and 46.2% (hyperkeratotic type). The CR rates in the different histopathological classifications of AK were 80% (hypertrophic type), 81.8% (atrophic type) and 42.9% (bowenoid type). The results revealed that determining the clinical and histopathological type of AK was important for selecting a therapeutic method. The topical imiquimod treatment could be expected to be more effective for AK clinically classified as the erythematous type, or histopathologically classified as the atrophic or hypertrophic type. However, it would be expected to be less effective for the treatment of AK clinically classified as the hyperkeratotic type or histopathologically classified as the bowenoid type. Our observations suggest that we can predict the efficacy of topical imiquimod therapy in AK by determining its clinical and histopathological type.

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Section: Discussionmentioning

confidence: 99%

“…Actinic keratosis (AK) is a precancerous lesion of squamous cell carcinoma (SCC) on the sun‐exposed skin of older individuals, and recent epidemiological studies have reported that there has been an increase in the number of AK patients along with the aging of society …”

Section: Introductionmentioning

confidence: 99%