5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects

Higashikawa, Fumiko; Noda, Masafumi; Awaya, Tomokazu; Tanaka, Tohru; Sugiyama, Masanori

doi:10.1016/j.nut.2013.02.008

Cited by 44 publications

(51 citation statements)

References 36 publications

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“…In this study, the plasma insulin levels of ALA/ SFC-administered ZDF rats were not different from those of vehicle-administered rats. This finding is consistent with the results of the previous study in which prediabetes patients were administered ALA/SFC for 12 weeks, and the fasting insulin levels were not affected [25]. Decreased pancreatic b-cell mass is associated with development of T2DM [41,42].…”

Section: Discussionsupporting

confidence: 92%

“…There are two previous large‐scale intervention studies in which ALA combined with sodium ferrous citrate (ALA/SFC) was administered to prediabetes volunteers . Rodriguez et al .…”

mentioning

confidence: 99%

“…Higashikawa et al . also studied subjects with mild hyperglycemia selected from the general population in Hiroshima, Japan, and reported that the oral administration of ALA/SFC for 12 weeks reduced the fasting and 2‐h post‐OGTT plasma glucose levels without adverse events. These reports suggest that ALA/SFC improves glucose tolerance in prediabetes subjects.…”

mentioning

confidence: 99%

“…There are two previous large-scale intervention studies in which ALA combined with sodium ferrous citrate (ALA/SFC) was administered to prediabetes volunteers [24,25]. Rodriguez et al [24] reported that the oral administration of ALA/SFC for 12 weeks improved the glucose levels of 2-h postoral glucose tolerance test (OGTT) in prediabetes volunteers in Hawaii.…”

mentioning

confidence: 99%

“…These improved levels were particularly noticeable in prediabetes subjects with 2-h post-OGTT baseline levels of ≥ 140 mgÁdL À1 (7.8 mmolÁL À1 ), who displayed significantly better glucose-lowering effects compared to those with baseline levels of < 140 mgÁdL À1 . Higashikawa et al [25] also studied subjects with mild hyperglycemia selected from the general population in Hiroshima, Japan, and reported that the oral administration of ALA/SFC for 12 weeks reduced the fasting and 2-h post-OGTT plasma glucose levels without adverse events. These reports suggest that ALA/SFC improves glucose tolerance in prediabetes subjects.…”

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confidence: 99%

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Combination of 5‐aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats

et al. 2016

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Mitochondrial dysfunction is associated with type 2 diabetes mellitus (T2 DM ). 5‐Aminolevulinic acid ( ALA ), a natural amino acid produced only in the mitochondria, is a precursor of heme. Cytochromes that contain heme play an important role in aerobic energy metabolism. Thus, ALA may help reduce T2 DM ‐associated hyperglycemia. In this study, we investigated the effect of ALA combined with sodium ferrous citrate ( SFC ) on hyperglycemia in Zucker diabetic fatty ( ZDF ) rats. We found that the gavage administration of ALA combined with SFC ( ALA / SFC ) for 6 weeks reduced plasma glucose and hemoglobin A1c (HbA1c) levels in rats without affecting plasma insulin levels. The glucose‐lowering effect depended on the amount of ALA / SFC administered per day. Furthermore, the glucose tolerance was also significantly improved by ALA / SFC administration. Although food intake was slightly reduced in the rats administered ALA / SFC , there was no effect on their body weight. Importantly, ALA / SFC administration induced heme oxygenase‐1 ( HO ‐1) expression in white adipose tissue and liver, and the induced expression levels of HO ‐1 correlated with the glucose‐lowering effects of ALA / SFC . Taken together, these results suggest that ALA combined with ferrous ion is effective in reducing hyperglycemia of T2 DM without affecting plasma insulin levels. HO ‐1 induction may be involved in the mechanisms underlying the glucose‐lowering effect of ALA / SFC .

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Section: Discussionsupporting

confidence: 92%

“…There are two previous large‐scale intervention studies in which ALA combined with sodium ferrous citrate (ALA/SFC) was administered to prediabetes volunteers . Rodriguez et al .…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Combination of 5‐aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats

et al. 2016

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5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila

et al. 2021

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Declines in mitochondrial functions are associated with aging. The combination of 5‐aminolevulinic acid (5‐ALA) and sodium ferrous citrate (SFC) improves mitochondrial functions in cultured cells. In this study, we investigated the effects of dietary supplementation with 5‐ALA and SFC (5‐ALA/SFC) on the healthspan and life span of Drosophila melanogaster . Adult Drosophila fruit flies were fed cornmeal food containing various concentrations of 5‐ALA/SFC. Locomotor functions, life span, muscle architecture, and age‐associated changes in mitochondrial function were analyzed. We found that feeding 5‐ALA/SFC mitigated age‐associated declines in locomotor functions and extended organismal life span. Moreover, 5‐ALA/SFC preserved muscle architecture and maintained the mitochondrial membrane potential in aged animals. Since 5‐ALA phosphate/SFC is used as a human dietary supplement, our results suggest that it could be used to slow the age‐related declines in muscle functions, prevent age‐associated clinical conditions such as frailty, and extend healthspan and life span.

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Low‐dose photodynamic therapy effect on closure of scratch wounds of normal and diabetic fibroblast cells: An in vitro study

Khorsandi

Fekrazad

Hamblin

2021

Journal of Biophotonics

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5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects

Cited by 44 publications

References 36 publications

Combination of 5‐aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats

Combination of 5‐aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats

5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila

Low‐dose photodynamic therapy effect on closure of scratch wounds of normal and diabetic fibroblast cells: An in vitro study

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