volume 143, issue 1-2, P58-65 2006
DOI: 10.1016/j.chemphyslip.2006.06.006
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Abstract: Currently, the detailed regulation of major pathways of glycerophospholipid synthesis upon cholesterol loading is largely unknown. Therefore, a detailed lipid metabolic profiling using stable isotope labeled choline, ethanolamine and serine was performed by quantitative electrospray ionization tandem mass spectrometry (ESI-MS/MS) in free cholesterol (FC), oxidized (Ox-LDL) and enzymatically modified LDL (E-LDL) loaded primary human skin fibroblasts. As previously described, an adaptive induction of phosphatid…

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