47-LB: Impact of Activity Intensity on Glucose Variability among Adolescents with Type 1 Diabetes

Abstract

Studies have consistently shown improvements in daily glucose and hemoglobin A1c (HbA1c) for both type 1 and type 2 diabetes with increased moderate and/or vigorous physical activity (PA). A limitation with prior investigations is that they only tested this relationship in adult populations and seldom looked at glucose variability (GV). Whether or not similar results would be observed in a pediatric population with type 1 diabetes (T1D) is unknown. Purpose: The purpose of this investigation was to test the relationship between GV and intensity of PA, and if duration of activity is predictive of changes in GV in a sample of teenagers with T1D. Methods: Data for this investigation were used from an ongoing study at a local pediatric Diabetes Center. Participants who wore a continuous glucose monitor (CGM) and Fitbit consecutively for a period of two weeks or more were included in the data analysis. GV was determined using 2-weeks of CGM data and PA intensity time was retrieved through Fitabase. Pearson’s correlation and a simple linear regression were used for final analysis with a p-value of 0.05 to determine significance. Results: Minutes of daily moderate intensity activity had a significant inverse relationship (r= -0.59; p = 0.04) with GV, whereas moderate and vigorous PA (MVPA) combined showed a stronger inverse relationship (r= -0.86; p = 0.03). When placed in a simple linear regression only MVPA significantly predicted changes in glucose variability (β= -0.12, p=0.03). Conclusion: These data show that not only is duration of PA an important factor when it comes to managing diabetes, but that more attention should be paid to the time spent at various intensity levels. Although more research is needed to determine feasibility it could be of great benefit for individuals managing diabetes to incorporate an activity monitor into their daily routine to share with their diabetes care team to better understand how PA levels impact their blood glucose. Disclosure J.R. Jaggers: None. K. King: None. T.E. McKay: None. R.J. Dyess: None. K.A. Wintergerst: None.