Abstract:Background Natural killer cells (NKs) expressing chimeric antigen receptors (CAR-NKs) were successful in hematological malignancies. 1 However, solid tumors resist CAR-NKs via a tumor microenvironment (TME) that includes myeloid derived suppressor cells (MDSCs) and M2 macrophages (M2s). 2 We demonstrated that ex vivo manufacture of therapeutic CAR-NKs significantly upregulated T cell immunoreceptor with Ig and ITIM domains (TIGIT), an inhibitory NK receptor. Analysis of pediatric neuroblastoma and sarcoma pati… Show more
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