Biochemical Pharmacology volume 81, issue 10, P1211-1218 2011 DOI: 10.1016/j.bcp.2011.03.005 View full text
Florastina Payton, Rumu Bose, William L. Alworth, Addanki P. Kumar, Rita Ghosh

Abstract: There has been a steady rise in fatalities associated with thick melanomas (>4mm). Although understanding of the biology of the disease has improved, effective treatment strategies for patients with advanced metastatic melanoma remain elusive. Therefore, more intensive testing of agents with therapeutic potential are needed to improve survival of patients with metastatic malignant melanoma. We have tested the ability of 4-methylcatechol, a metabolite of quercetin; a naturally occurring compound that is common…

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