3D printing of tough hydrogels based on metal coordination with a two-step crosslinking strategy

Guo, Gang; Wu, Yi; Du, Cong; Wu, Zi Liang; Yin, Jun; Zheng, Qiang; Qian, Jin

doi:10.1039/d1tb02529e

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…However, the viscosity of the mixed solution gradually increased via the Michael addition reaction between MCS and SHHA (Figure S3, Supporting Information), which was conducive to fixing the shape of 3D structures. [31,45] Therefore, it can be shown that the photopolymerization (acrylate-thiol step-chain polymerization and acrylate-acrylate chain polymerization) was still the main reaction route to form MCS/SHHA hydrogels while the acrylate-thiol Michael addition reaction can play a small role in the 3D printing.…”

Section: Rheological Studymentioning

confidence: 99%

“…In this stage, the viscosity of the mixed solution gradually increased via the Michael addition reaction between MCS and SHHA (Figure S3, Supporting Information), which was conducive to fixing the shape of the 3D structure. [31,45] Second, the acrylate-thiol step-chain polymerization and acrylate-acrylate chain polymerization were conducted by exposing the ink fibers to UV light during the printing process. The above reactions were formed instantaneously, and acrylate-thiol step-chain polymerization could occur with less oxygen-inhibition effect than traditional acrylate-acrylate chain polymerization.…”

Section: D Printingmentioning

confidence: 99%

“…[29] In regard to photopolymerization, it may have low initial viscosity of inks and the oxygen inhibition effect, resulting in incomplete printed structures and interface defects. [30,31] To solve the above problems, in this work, we proposed the synthesis of photopolymerizable hydrogels based on two naturally derived polysaccharides: chitosan (CS) and hyaluronic acid (HA). CS has good biodegradability, anti-microbial ability, and mucosal adhesion, [32,33] while HA has an excellent physiological function that can not only maintain the water content of cells and the integrity of the intercellular substance but also interact with specific cell receptors (e.g., CD44, HARE, ICAM-1 and RHAMM) to regulate cell processes.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naturally Derived Maleic Chitosan/Thiolated Sodium Hyaluronate Hydrogels as Potential 3D Printing Tissue Engineering Materials

Zhang,

Peng,

Huang

et al. 2023

Macro Materials & Eng

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Abstract3D printing is an attractive method to accurately construct artificial organs or alternative materials with complicated structures and functional performance. Naturally derived hydrogels have emerged as promising materials for the preparation of biomimetic 3D organization or scaffolds by 3D printing due to their good biocompatibility, high water content, and fascinating 3D network. However, the poor printing properties and weak structural stability of naturally derived hydrogels limit their applications. In this study, photopolymerizable hydrogels are designed based on maleic chitosan (MCS) and thiolated sodium hyaluronate (SHHA). The Michael addition between MCS and SHHA improves the viscosity of the mixed solution. Moreover, it benefits the 3D printing process, followed by photopolymerization (acrylate‐thiol step‐chain polymerization and acrylate–acrylate chain polymerization) to form a stable covalent network rapidly. The rheological property, swelling behaviors, microstructure, and in vitro degradation are tuned by adjusting the molar ratio of the thiol group and acrylate group. In addition, MCS/SHHA hydrogel scaffolds with good accuracy and enhanced structural stability are prepared using extrusion‐based 3D printing and photopolymerization technology. The hydrogels display excellent cytocompatibility and can support adherence of L929 cells, which can be used as prospective materials for tissue engineering applications.

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Section: Rheological Studymentioning

confidence: 99%

Section: D Printingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Naturally Derived Maleic Chitosan/Thiolated Sodium Hyaluronate Hydrogels as Potential 3D Printing Tissue Engineering Materials

Zhang,

Peng,

Huang

et al. 2023

Macro Materials & Eng

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“…On the other hand, hydrogels prepared by covalent cross-linking are more mechanically stable than the physically cross-linked ones, which is a major advantage for applications such as wastewater treatment. Different covalent cross-linking strategies have been applied to prepare them, including condensation, Schiff base, or click-chemistry reactions, depending on the reactivity of polymer functional groups [ 39 , 47 , 48 , 49 ]. However, if small difunctional organic molecules (dialdehydes, dianhydrides, epichlorohydrin (ECH), diglycidyl ethers, etc.)…”

Section: Polysaccharide-based Composite Hydrogels—design Principles A...mentioning

confidence: 99%

Polysaccharide-Based Composite Hydrogels as Sustainable Materials for Removal of Pollutants from Wastewater

Ghiorghiță¹,

Dinu²,

Lazăr³

et al. 2022

Molecules

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Nowadays, pollution has become the main bottleneck towards sustainable technological development due to its detrimental implications in human and ecosystem health. Removal of pollutants from the surrounding environment is a hot research area worldwide; diverse technologies and materials are being continuously developed. To this end, bio-based composite hydrogels as sorbents have received extensive attention in recent years because of advantages such as high adsorptive capacity, controllable mechanical properties, cost effectiveness, and potential for upscaling in continuous flow installations. In this review, we aim to provide an up-to-date analysis of the literature on recent accomplishments in the design of polysaccharide-based composite hydrogels for removal of heavy metal ions, dyes, and oxyanions from wastewater. The correlation between the constituent polysaccharides (chitosan, cellulose, alginate, starch, pectin, pullulan, xanthan, salecan, etc.), engineered composition (presence of other organic and/or inorganic components), and sorption conditions on the removal performance of addressed pollutants will be carefully scrutinized. Particular attention will be paid to the sustainability aspects in the selected studies, particularly to composite selectivity and reusability, as well as to their use in fixed-bed columns and real wastewater applications.

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Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness

Liu

Jiang

Wang

et al. 2023

Adv Funct Materials

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Biomimicking organ phantoms with vivid biological structures and soft and slippery features are essential for in vitro biomedical applications yet remain hither to unmet challenges in their fabrication such as balancing between spatial structural complexity and matchable mechanical properties. Herein, 3D printable tissue-mimicking elastomeric double network hydrogels with tailorable stiffness are evolved to idiosyncratically match diverse biological soft tissues by regulating the compositions of hydrogel matrix and the density of metal coordination bonds. Relying on digital light processing 3D printing, various mechanically tunable biomimetic volumetric hydrogel organ constructs with structural complexity and fidelity, including kidney, brain, heart, liver, stomach, lung, trachea, intestine, and even the intricate vascularized tissues, are fabricated faultlessly. Proof-of-concept 3D printed hydrogel heart and liver phantoms provide sophisticated internal channels and cavity structures and external realistic anatomical architectures that more closely mimic native organs. For the in vitro application demonstration, a 3D printed hydrogel brain phantom with tortuous cerebral arteries and slippery characters serves as an effective neurosurgical training platform for realistic simulation of endovascular interventions. This platform offers a means to construct mechanically precisely tunable hydrogel-based biomimetic organ phantoms that are expected to be used in surgical training, medical device testing, and organs-on-chips.

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3D printing of tough hydrogels based on metal coordination with a two-step crosslinking strategy

Abstract: We demonstrate the self-supporting 3D printing of complex hydrogel structures based on simultaneous crosslinking reaction while printing. The printing strategy is based on Schiff’s base reaction and metal coordination with...

Cited by 7 publications

References 34 publications

Naturally Derived Maleic Chitosan/Thiolated Sodium Hyaluronate Hydrogels as Potential 3D Printing Tissue Engineering Materials

Naturally Derived Maleic Chitosan/Thiolated Sodium Hyaluronate Hydrogels as Potential 3D Printing Tissue Engineering Materials

Polysaccharide-Based Composite Hydrogels as Sustainable Materials for Removal of Pollutants from Wastewater

Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness

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