3D printed materials for combating antimicrobial resistance

Doganay, Mert Tunca; John Chelliah, Cyril; Tozluyurt, Abdullah; Hujer, Andrea M.; Obaro, Stephen K.; Gurkan, Umut; Patel, Robin; Bonomo, Robert A.; Draz, Mohamed

doi:10.1016/j.mattod.2023.05.030

Cited by 7 publications

(5 citation statements)

References 164 publications

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“…In some antibacterial materials, the microbicidal effect is achieved by releasing the active agent into the surrounding environment. 11 The release rate primarily depends on the material composition, biocide properties, and the methods employed for material preparation. However, the main drawback is that the release of the agent implies that the material cannot be reused.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In particular, for the design of 3D biocidal platforms, filaments based on PLA composites with metal-based nanoparticles have been developed. 11 However, akin to antibiotics, prolonged exposure to sublethal doses of antimicrobial agents may contribute to the emergence of resistant bacteria. Another commonly employed method for germ removal from water is filtration, which relies on size exclusion to dismiss microbes.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In recent years, there has been a significant increase in the fabrication of materials combining PLA with antimicrobial agents. In particular, for the design of 3D biocidal platforms, filaments based on PLA composites with metal-based nanoparticles have been developed . However, akin to antibiotics, prolonged exposure to sublethal doses of antimicrobial agents may contribute to the emergence of resistant bacteria.…”

Section: Resultsmentioning

confidence: 99%

“…7,8 Additionally, PLA can be combined with various additives to enhance its properties and acquire specific functionalities, 9,10 including antimicrobial activity. 11 Furthermore, in the past decade, it has become one of the most-used materials in three-dimensional (3D) printing or fused deposition modeling (FDM). 12 This technique employs a thermoplastic filament to create objects previously designed using computer-aided design (CAD) software.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Polylactic acid (PLA) is a polymer that has gained approval from the Food and Drug Administration for various clinical and ecological applications . PLA offers several advantages over other materials, such as poly(ethylene terephthalate) (PET) and acrylonitrile butadiene styrene (ABS), especially from an environmentally friendly perspective. , Additionally, PLA can be combined with various additives to enhance its properties and acquire specific functionalities, , including antimicrobial activity . Furthermore, in the past decade, it has become one of the most-used materials in three-dimensional (3D) printing or fused deposition modeling (FDM) .…”

Section: Introductionmentioning

confidence: 99%

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Polylactic Acid Filament Containing Boron-Dipyrromethene (BODIPY) for Singlet Oxygen Generation in Photoactivatable Antimicrobial Objects

Gómez,

Chávez Hernández,

de Prada

et al. 2024

ACS Appl. Polym. Mater.

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Antimicrobial materials are required to diminish the propagation of infectious diseases. Exploiting photosensitization of cytotoxic singlet oxygen ( 1 O 2 ), we report a strategy for manufacturing an antimicrobial filament by combining a halogenated boron-dipyrromethene (BODIPY) photosensitizer (PS) with polylactic acid (PLA). The filament (PLA PS ) was then used to three-dimensional (3D)-print square-shaped objects and meshes, facilitating material characterization and testing. The results demonstrate that the spectroscopic characteristics of the PS entrapped in the polymeric matrix are preserved, including its photostability. These properties were maintained after two cycles of recycling, proving the reusability of PLA PS . Irradiation of the material with green light triggers 1 O 2 , as evidenced by oxidation of a water-soluble anthracene derivative and direct detection of 1 O 2 luminescence experiments. Fluorescence microscopy studies, assessing real-time bacterial inactivation on the material's surface, indicate complete elimination of Pseudomonas aeruginosa in the imaging region after 40 min of irradiation with a low light dose (1.6 J/cm 2 ). Furthermore, a prototype of a water treatment apparatus was assembled and successfully inactivated 99.9% of Shigella dysenteriae, a typical waterborne pathogen. This sets the stage and opens diverse avenues for a cost-effective and straightforward design of sustainable 3D materials for light-mediated microbial deactivation.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polylactic Acid Filament Containing Boron-Dipyrromethene (BODIPY) for Singlet Oxygen Generation in Photoactivatable Antimicrobial Objects

Gómez,

Chávez Hernández,

de Prada

et al. 2024

ACS Appl. Polym. Mater.

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3D Printable Antimicrobial Polymer Blend

Daniels,

Rautenbach,

du Plessis

et al. 2024

Macro Materials & Eng

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Three‐dimensional (3D) printing is an innovative manufacturing method for preparing designer materials with complex geometries. However, there are very few studies on the fabrication of antimicrobial polymer materials suitable for use in everyday clinical objects, via 3D printing. In this work, an antibacterial polymer material is prepared by blending polyamide 11 (matrix), a high‐performance engineering thermoplastic, and a styrene maleimide copolymer with pendant quaternary amine moieties, and the blend 3D printed via selective laser sintering. The quaternary amine functionalities confer permanent antimicrobial properties. Blend properties are studied prior to printing via differential scanning calorimetry, powder X‐ray diffraction, and FTIR spectroscopy. Additionally, the mechanical and antimicrobial properties of the polymer blends and printed material are also assessed. The microstructure of the 3D printed polymer materials is further characterized via DOSY NMR spectroscopy. This study indicates that this is a promising approach for preparing nonleaching antimicrobial 3D printable materials.

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