3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration

Koo, YoungWon; Choi, Eunji; Lee, JaeYoon; Kim, Hanjun; Kim, GeunHyung

doi:10.1016/j.jiec.2018.05.049

Cited by 65 publications

(49 citation statements)

References 39 publications

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“…[63]). 42) and (43), the red one represents its approximation (44), which neglects the correlations between GMCF amplitudes, and the green line is the approximation of independent units (45). At h/l = 150, the total intensity is well approximated by the both approximations in the fractal region.…”

Section: A Generalized Surface Cantor Fractalmentioning

confidence: 99%

The structure of deterministic mass and surface fractals: theory and methods of analyzing small-angle scattering data

Cherny

Anitas

Osipov

et al. 2019

Phys. Chem. Chem. Phys.

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Small-angle scattering (SAS) of X-rays, neutrons or light from ensembles of randomly oriented and placed deterministic fractal structures are studied theoretically. In the standard analysis, a very few parameters can be determined from SAS data: the fractal dimension, and the lower and upper limits of the fractal range. The self-similarity of deterministic structures allows one to obtain additional characteristics of their spatial structures. The paper considers models which can describe accurately SAS from such structures. The developed models of deterministic fractals offer many advantages in describing fractal systems, including the possibility to extract additional structural information, an analytic description of SAS intensity, and effective computational algorithms. Generalized Cantor fractals and few of its variants are used as basic examples to illustrate the above concepts and to model physical samples with mass, surface, and multi-fractal structures. The differences between the deterministic and random fractal structures in analyzing SAS data are emphasized. Several limitations are identified in order to motivate future investigations of deterministic fractal structures.

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Section: A Generalized Surface Cantor Fractalmentioning

confidence: 99%

The structure of deterministic mass and surface fractals: theory and methods of analyzing small-angle scattering data

Cherny

Anitas

Osipov

et al. 2019

Phys. Chem. Chem. Phys.

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“…Additionally, combinations thereof may be used in order to obtain end-use-specific properties. Thus, hydrogels based on different natural polymers (alginate [ 10 , 11 ], gelatin [ 12 , 13 ], cellulose [ 14 , 15 ], collagen [ 16 , 17 , 18 ], fibrinogen [ 19 , 20 ], hyaluronic acid [ 21 , 22 , 23 ]) or synthetic polymers (such as polyacrylamide [ 24 , 25 ], polyurethane [ 26 , 27 , 28 , 29 ], poly-(ethylene glycol) [ 30 , 31 ]) have been explored for the development of biomaterial inks. Naturally sourced bioactive polymers demonstrate superior biofunctionality over synthetic ones.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

et al. 2021

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The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. The biopolymeric matrix consisted of methacrylated gelatin (GelMA). Several types of nanoclay were added as the inorganic component. Our aim was to investigate the influence of clay type on the rheological behavior of ink formulations and to determine the morphological and structural properties of the resulting crosslinked hydrogel-based nanomaterials. Moreover, through the inclusion of nanoclays, our goal was to improve the printability and shape fidelity of nanocomposite scaffolds. The viscosity of all ink formulations was greater in the presence of inorganic nanoparticles as shear thinning occurred with increased shear rate. Hydrogel nanocomposites presented predominantly elastic rather than viscous behavior as the materials were crosslinked which led to improved mechanical properties. The inclusion of nanoclays in the biopolymeric matrix limited hydrogel swelling due the physical barrier effect but also because of the supplementary crosslinks induced by the clay layers. The distribution of inorganic filler within the GelMA-based hydrogels led to higher porosities as a consequence of their interaction with the biopolymeric ink. The present study could be useful for the development of soft nanomaterials foreseen for the additive manufacturing of customized implants for tissue engineering.

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“…Unfortunately, cartilage is an avascular and nervefree tissue, and its healing/self-regeneration upon damage remains a significant clinical challenge 3 . To date, various hydrogel systems, such as injectable hydrogels 4 and 3D printed cell-laden hydrogels 5 , have been deployed as bioscaffolds for articular cartilage tissue engineering 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions

et al. 2020

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The inability of damaged load-bearing cartilage to regenerate and self-repair remains a long-standing challenge in clinical settings. In the past, the use of PVA hydrogels as cartilage replacements has been explored; however, both pristine and annealed PVA are not ideal for load-bearing cartilage applications, and new materials with improved properties are highly desirable. In this work, we developed a novel hybrid hydrogel system consisting of glycerolmodified PVA hydrogel reinforced by a 3D printed PCL-graphene composite scaffold. The composition of the hydrogel within the hybrid material was optimized to achieve high water retention and enhanced stiffness. The hybrid hydrogel formed by reinforcement with a 3D printed PCL-graphene scaffold with optimized architecture demonstrated desirable mechanical properties (stiffness, toughness, and tribological properties) matching those of natural loadbearing cartilage. Our novel hydrogel system has also been designed to provide drug release and on-demand photothermal conversion functions and at the same time offers excellent biocompatibility with low cell adhesion. These promising properties may allow our unique hybrid hydrogel system to be used for potential applications, such as load-bearing cartilage repair/replacement, as well as targeting certain challenging clinical conditions, such as the treatment of severe arthritis.

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3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration

Cited by 65 publications

References 39 publications

The structure of deterministic mass and surface fractals: theory and methods of analyzing small-angle scattering data

The structure of deterministic mass and surface fractals: theory and methods of analyzing small-angle scattering data

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions

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