3D Particle Tracking for Noninvasive In Vivo Analysis of Synaptic Microtubule Dynamics in Dendrites and Neuromuscular Junctions of Drosophila

Chou, Vivian T.; Yesilyurt, Hunkar Gizem; Lai, Hoyin; Long, Jennifer B.; Arnés, Mercedes; Obbad, Kamal; Jones, Michael W. M.; Sasaki, Hideki; Lucas, Luciano; Alworth, S.; Lee, James Shih-Jong; Vactor, David Van

doi:10.3791/61159

Cited by 1 publication

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“…Even in these cases, however, there are difficulties to overcome. The probe could be toxic, or it could be bundling, somehow altering the polymerization/depolymerization dynamics of the various structures of the cytoskeleton or modifying the binding site of proteins associated with the cytoskeleton [ 85 , 86 , 87 , 88 ].…”

Section: Microscopic Approaches To Visualize and Assess Cytoskeleton ...mentioning

confidence: 99%

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria

Alberti

Semperboni

Cavaletti

et al. 2022

Cells

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Neurons are permanent cells whose key feature is information transmission via chemical and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain function and preserve neuronal lifelong survival. The cytoskeleton, and in particular microtubules, are far from being inert actors in the maintenance of this complex cellular equilibrium, and they participate in the mobilization of molecular cargos and organelles, thus influencing neuronal migration, neuritis growth and synaptic transmission. Notably, alterations of cytoskeletal dynamics have been linked to alterations of neuronal excitability. In this review, we discuss the characteristics of the neuronal cytoskeleton and provide insights into alterations of this component leading to human diseases, addressing how these might affect excitability/synaptic activity, as well as neuronal functioning. We also provide an overview of the microscopic approaches to visualize and assess the cytoskeleton, with a specific focus on mitochondrial trafficking.

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Section: Microscopic Approaches To Visualize and Assess Cytoskeleton ...mentioning

confidence: 99%

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria

Alberti

Semperboni

Cavaletti

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

3D Particle Tracking for Noninvasive In Vivo Analysis of Synaptic Microtubule Dynamics in Dendrites and Neuromuscular Junctions of Drosophila

Cited by 1 publication

References 0 publications

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria

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