3d Mechanical properties of the partially obstructed guinea pig small intestine

Liao, Donghua; Zhao, Jingbo; Gregersen, Hans

doi:10.1016/j.jbiomech.2010.04.008

Cited by 34 publications

(13 citation statements)

References 28 publications

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“…Experimental data suggests that the active force varies in between 0.6-0.9 gram during a spontaneous contraction of SMC [18]. According to Zhao et al [27], the muscle layer thickness of pig intestine is 0.9 ± 0.06 mm, and as per Liao et al [12], the muscle layer thickness is 1.03 ± 0.08 mm. Assuming the circular and longitudinal muscle layers are of the same thickness, the circular muscle layer thick- ness was calculated to be in between 0.42 mm to 0.55 mm.…”

Section: Resultsmentioning

confidence: 90%

An active finite viscoelastic model for gastric smooth muscle contraction

Panda

Buist

2021

Preprint

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A coupled electromechanical model to describe the transduction process of cellular electrical activity into mechanical deformation has been presented. The model consolidates a biophysical smooth muscle cell model, a biophysical actin-myosin interaction model, a sliding filament model and a viscoelastic constitutive model to construct an active finite viscoelastic model. The key input to this model is an electrical pulse which then estimates the resulting stress and deformation in the cell. The proposed model was used to recreate experimental observations performed on canine and porcine gastric tissue strips. In all cases, the simulation results were well matched with the experimental data (R2> 0.9).

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Section: Resultsmentioning

confidence: 90%

An active finite viscoelastic model for gastric smooth muscle contraction

Panda

Buist

2021

Preprint

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“…Such a model was previously proposed for capturing the behavior of arteries [49,53], myocardium [54], and epicardium [55], among others. Other studies have considered nonzero stress along the thickness of the tissue [35,42], shear in the θ − z plane [38,39],…”

Section: Phenomenological Modelsmentioning

confidence: 99%

Biomechanical Constitutive Modeling of the Gastrointestinal Tissues: Where Are We?

Patel¹,

Gizzi²,

Hashemi³

et al. 2021

Preprint

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The gastrointestinal (GI) tract is a continuous channel through the body that consists of the esophagus, the stomach, the small intestine, the large intestine, and the rectum. Its primary functions are to move the intake of food for digestion before storing and ultimately expulsion of feces from the rectum through the anal sphincter. The mechanical behavior of GI tissues thus plays a crucial role for GI function in health and disease. The mechanical properties are typically characterized by a constitutive biomechanical model, which is a mathematical representation of the relation between load and deformation in a tissue. Hence, validated biomechanical constitutive models are essential to characterize and simulate the mechanical behavior of the GI tract under physiological and pathological conditions. Numerous constitutive models have consequently been proposed over the past three decades, mainly inspired by work done in cardiovascular tissues. Here, a comprehensive review of these constitutive models is provided. This review is limited to studies where a model of the strain energy function is proposed to characterize the stress-strain relation of a GI tissue. Several needs are identified for more advanced modeling of GI biomechanics including: 1) Microstructural models that provide actual structure-function relations; 2) Validation of coupled electro-mechanical models accounting for active muscle contractions; 3) Human data under physiological and pathological conditions to develop and validate models. The findings from this review provide guidelines for using existing constitutive models as well as perspective and directions for future studies aimed at establishing new constitutive models for GI tissues.

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“…The mechanics of gastrointestinal tissue is much less explored than the one of cardiovascular tissue. There have been a few papers on the constitutive behavior of the esophagus, small intestine, and large intestine, and around 20 on the mechanical properties of the gastric wall. These revealed that the constitutive properties and thickness of the different layers of the gastric wall differ significantly between different regions of the stomach, corresponding to their respective physiological functions.…”

Section: Anatomy and Physiology Of The Human Stomachmentioning

confidence: 99%

Mechanics of the stomach: A review of an emerging field of biomechanics

et al. 2019

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Mathematical and computational modeling of the stomach is an emerging field of biomechanics where several complex phenomena, such as gastric electrophysiology, fluid mechanics of the digesta, and solid mechanics of the gastric wall, need to be addressed. Developing a comprehensive multiphysics model of the stomach that allows studying the interactions between these phenomena remains one of the greatest challenges in biomechanics. A coupled multiphysics model of the human stomach would enable detailed in‐silico studies of the digestion of food in the stomach in health and disease. Moreover, it has the potential to open up unprecedented opportunities in numerous fields such as computer‐aided medicine and food design. This review article summarizes our current understanding of the mechanics of the human stomach and delineates the challenges in mathematical and computational modeling which remain to be addressed in this emerging area.

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3d Mechanical properties of the partially obstructed guinea pig small intestine

Cited by 34 publications

References 28 publications

An active finite viscoelastic model for gastric smooth muscle contraction

An active finite viscoelastic model for gastric smooth muscle contraction

Biomechanical Constitutive Modeling of the Gastrointestinal Tissues: Where Are We?

Mechanics of the stomach: A review of an emerging field of biomechanics

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