3D In-Vivo Optical Skin Imaging for Topographical Quantitative Assessment of Non-Ablative Laser Technology

Friedman, Paul M.; Skover, Greg R.; Payonk, Greg S.; Kauvar, Arielle N. B.; Geronemus, Roy G.

doi:10.1046/j.1524-4725.2002.02832.x

Cited by 106 publications

(81 citation statements)

References 21 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The wrinkle profile recording was performed by using the optical 3D in vivo measurement system PRIMOS (Phaseshift Rapid In vivo Measurement Of Skin) (GFMesstechnik GmbH, Teltow, Germany). The system is based on the digital fringe projection technique as described by Jaspers et al [29], and has been validated for rhytide assessment in several clinical studies [30][31][32]. Briefly, a parallel stripe pattern is projected onto the skin surface by using micro-mirrors and recorded by a CCD camera.…”

Section: Discussionmentioning

confidence: 99%

“…The 3D effect is achieved by the minute elevation differences on the skin surface, which deflect the parallel projection stripes. The measurements of these deflections provide qualitative and quantitative data of the skin profile and therefore allow the assessment of the effect of laser skin resurfacing [30]. The PRIMOS measurement was performed with a facial camera mount (Canfield Scientific, Inc., Fairfield, NJ) that was left in place for the photographic documentation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

et al. 2010

View full text Add to dashboard Cite

Background and Objective: Ablative fractional lasers were introduced for treating facial rhytides in an attempt to achieve results comparable to traditional ablative resurfacing but with fewer side effects. However, there is conflicting evidence on how well this goal has generally been achieved as well as on the comparative value of fractional CO 2 and Er:YAG lasers. The present study compares these modalities in a randomized controlled double-blind split-face study design. Study Design/Materials and Methods: Twenty-eight patients were enrolled and completed the entire study. Patients were randomly assigned to receive a single treatment on each side of the peri-orbital region, one with a fractional CO 2 and one with a fractional Er:YAG laser. The evaluation included the profilometric measurement of wrinkle depth, the Fitzpatrick wrinkle score (both before and 3 months after treatment) as well as the assessment of side effects and patient satisfaction (1, 3, 6 days and 3 months after treatment). Results: Both modalities showed a roughly equivalent effect. Wrinkle depth and Fitzpatrick score were reduced by approximately 20% and 10%, respectively, with no appreciable difference between lasers. Side effects and discomfort were slightly more pronounced after Er:YAG treatment in the first few days, but in the later course there were more complaints following CO 2 laser treatment. Patient satisfaction was fair and the majority of patients would have undergone the treatment again without a clear preference for either method. Conclusions: According to the present study, a single ablative fractional treatment session has an appreciable yet limited effect on peri-orbital rhytides. When fractional CO 2 and Er:YAG lasers are used in such a manner that there are comparable post-operative healing periods, comparable cosmetic improvement occurs. Multiple sessions may be required for full effect, which cancels out the proposed advantage of fractional methods, that is, fewer side effects and less down time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The three-dimensional optical measurement of each replica was depicted using PRIMOS Compact (GF Messtechnik GmbH, Berlin, Germany), as previously reported. [52][53][54][55][56] After measurement, moiré fringes were eliminated, and an analytical straight line (7 to 9 mm) was drawn on each replica. Along this line, linear roughness parameter values were assessed.…”

Section: Skin Profilometric Measurementmentioning

confidence: 99%

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

Hachiya

Sriwiriyanont

Fujimura

et al. 2009

The American Journal of Pathology

View full text Add to dashboard Cite

UVB irradiation has been reported to induce photoaging and suppress systemic immune function that could lead to photocarcinogenesis. However, because of the paucity of an UVB-induced photodamaged skin model, precise and temporal mechanism(s) underlying the deleterious effects of long-term UVB exposure on human skin have yet to be delineated. In this study, we established a model using human skin xenografted onto severe combined immunodeficient mice, which were subsequently challenged by repeated UVB irradiation for 6 weeks. Three-dimensional optical image analysis of skin replicas and noninvasive biophysical measurements illustrated a significant increase in skin surface roughness, similar to premature photoaging, and a significant loss of skin elasticity after long-term UVB exposure. Resembling authentically aged skin, UVB-exposed samples exhibited significant increases in epithelial keratins (K6, K16, K17), elastins, and matrix metalloproteinases (MMP-1, MMP-9, MMP-12) as well as degradation of collagens (I, IV, VII). The UVB-induced deterioration of fibrous keratin intermediate filaments was also observed in the stratum corneum. Additionally, similarities in gene expression patterns between our model and chronologically aged skin substantiated the plausible relationship between photodamage and chronological age. Furthermore , severe skin photodamage was observed when neutralizing antibodies against TIMP-1 , an endogenous inhibitor of MMPs , were administered during the UVB exposure regimen. Taken together , these findings suggest that our skin xenograft model recapitulates premature photoaged skin and provides a comprehensive tool with which to assess the deleterious effects of UVB irradiation.

show abstract

“…A special vacuum pump for mixing replica material is required and this can be expensive and time consuming. Laser triangulation and fringe projection based techniques have also been used for in-vivo 3D skin surface analysis [9], [10], however they are limited to small area measurements and are also costly. A Photometric stereo based approach requires a single camera and multiple light sources for acquisition.…”

Section: Existing Wrinkle Grading Systems and Imaging Techniquesmentioning

confidence: 99%

“…These replicas were then imaged using a PRIMOS 4® device and used as a ground truth. The PRIMOS device is based on the principle of structured light 3D imaging and has already proven to work for wrinkles and scar evaluation and efficacy testing of skin treatments [10], [22][23][24].…”

Section: Skin Replica and Ground Truthmentioning

confidence: 99%

3D In-Vivo Measurement of Skin Topography Using Photometric Stereo

Sohaib¹,

Farooq²,

Smith³

et al. 2012

Proceedings of the 3rd International Conference on 3D Body Scanning Technologies, Lugano, Switzerland, 16-17 October 2012

View full text Add to dashboard Cite

Increased demand for treatment of skin wrinkles has led to a proliferation of different pharmaceutical and surgical treatment methods. However there still remains a lack of quantitative, objective, easily utilizable and reproducible wrinkle classification system by which these treatments can be studied and compared. We propose the use of a novel photometric stereo based technique as a potentially efficient and economical way for quantitative evaluation of skin topography. Also presented is an algorithm for improving depth estimates of skin using photometric stereo and Fractals based technique for quantification of skin topography which unlike existing 2D roughness parameters makes use of complete 3D topographical information.

show abstract

3D In-Vivo Optical Skin Imaging for Topographical Quantitative Assessment of Non-Ablative Laser Technology

Cited by 106 publications

References 21 publications

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

3D In-Vivo Measurement of Skin Topography Using Photometric Stereo

Contact Info

Product

Resources

About

3D In-Vivo Optical Skin Imaging for Topographical Quantitative Assessment of Non-Ablative Laser Technology

Cited by 106 publications

References 21 publications

Ablative fractional lasers (CO2 and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Ablative fractional lasers (CO2 and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Mechanistic Effects of Long-Term Ultraviolet B Irradiation Induce Epidermal and Dermal Changes in Human Skin Xenografts

3D In-Vivo Measurement of Skin Topography Using Photometric Stereo

Contact Info

Product

Resources

About

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides