3D gait analysis, haemophilia joint health score, leg muscle laterality and biomarkers of joint damage: A cross‐sectional comparative assessment of haemophilic arthropathy

Abstract

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Joint Health Markers in Hemophilia: The State of the Art

“…Studies comparing hemophilia patients and control patients showed both increased and decreased levels of cartilage, bone and synovial inflammation markers [7,8,10,11,[19][20][21]. These discrepancies were also noticed in our initial systematic review.…”

Lower physical activity and altered body composition in patients with haemophilia compared with healthy controls

“…Associations between the HJHS and the physical activity parameters were assessed by Spearman's Rho. The targeted sample size of 24 PWH and 24 healthy controls was based on sample size calculation for the aforementioned primary study 19 . Differences in body composition between PWH and controls were additionally analysed in the subgroup of participants, who compliantly wore the accelerometer device for tracking physical activity.…”

“…Physical activity and body composition were recorded for this primary analysis in order to correct the primary effects for these potential confounding variables. 19 This prespecified secondary analysis aimed to evaluate physical activity patterns and body composition of adult PWH, by comparing these outcomes with those of healthy age-matched controls.…”

“…Findings reported in this paper represent a secondary analysis of data recorded as potential confounding variables in the JOSEPHA study (Joint‐health Outcome Scoring: Exploration in Patients with Haemophilia in Austria), where outcomes of 3D gait analyses, functional, and haematological assessments were primarily assessed. Physical activity and body composition were recorded for this primary analysis in order to correct the primary effects for these potential confounding variables 19 . This prespecified secondary analysis aimed to evaluate physical activity patterns and body composition of adult PWH, by comparing these outcomes with those of healthy age–matched controls.…”

Biomechanical Gait Analysis of an Adult with Severe Hemophilia: A Case Report

“…This analysis technique has been widely used as a functional diagnostic tool [ 8 ] to assist clinicians in their decision-making process to optimize the care of pathological individuals [ 9 ] such as hemophilic individuals [ 10 ]. In fact, previous studies have examined the gait patterns of individuals with hemophilia; however, they have reported only spatiotemporal parameters, joint angles, or pedobarography-related variables [ 11 , 12 , 13 ]. Few studies have employed 3D gait biomechanics to describe hemophilic gait patterns and most of those that did employ this technique had the subjects walk on a treadmill during the experiments [ 14 , 15 , 16 , 17 ].…”