3D Cross‐Point Plasmonic Nanoarchitectures Containing Dense and Regular Hot Spots for Surface‐Enhanced Raman Spectroscopy Analysis

Jeong, Jae Won; Arnob, Masud Parvez; Baek, Kwang-Min; Lee, Seung Yong; Shih, Wei-Chuan; Jung, Yeon Sik

doi:10.1002/adma.201602603

Cited by 187 publications

(133 citation statements)

References 60 publications

(76 reference statements)

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“…Nanostructures-on-f ilm Gold-nanofève substrates [58] Deposition EF ≈ 10 7 SR ≈ 11.0% • Ultrasensitive, quantitative analysis of biomolecules via direct SERS measurements 3D cross-point plasmonic nanoarchitectures [66] Nanotransfer printing…”

Section: -Mpy • Sensor Platform For Nanosized Biomolecules • Sers Namentioning

confidence: 99%

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

et al. 2019

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Precision oncology, defined as the use of the molecular understanding of cancer to implement personalized patient treatment, is currently at the heart of revolutionizing oncology practice. Due to the need for repeated molecular tumor analyses in facilitating precision oncology, liquid biopsies, which involve the detection of noninvasive cancer biomarkers in circulation, may be a critical key. Yet, existing liquid biopsy analysis technologies are still undergoing an evolution to address the challenges of analyzing trace quantities of circulating tumor biomarkers reliably and cost effectively. Consequently, the recent emergence of cutting-edge plasmonic nanomaterials represents a paradigm shift in harnessing the unique merits of surface-enhanced Raman scattering (SERS) biosensing platforms for clinical liquid biopsy applications. Herein, an expansive review on the design/synthesis of a new generation of diverse plasmonic nanomaterials, and an updated evaluation of their demonstrated SERS-based uses in liquid biopsies, such as circulating tumor cells, tumor-derived extracellular vesicles, as well as circulating cancer proteins, and tumor nucleic acids is presented. Existing challenges impeding the clinical translation of plasmonic nanomaterials for SERS-based liquid biopsy applications are also identified, and outlooks and insights into advancing this rapidly growing field for practical patient use are provided.

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Section: -Mpy • Sensor Platform For Nanosized Biomolecules • Sers Namentioning

confidence: 99%

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

et al. 2019

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“…The reproducibility can be confirmed by the small error bars in Figure b and the similar results from the repeated experiments using other two sets of enantiomers of the MCMs (Figure S13, Supporting Information). The excellent sensing capability of the MCMs is attributed to the compact hot spots (as shown in Figure ) in the 3D chiral scaffolds and the connected 3D nanopores that allow facile penetration of the molecules …”

mentioning

confidence: 99%

Moiré Chiral Metamaterials

Zheng

2017

Advanced Optical Materials

117

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nanostructures as building blocks. The excitation of the light-coupled collective resonances of free electrons in plasmonic nanostructures leads to the strong lightmatter interactions at the subwavelength scale. The chiral configuration makes the interactions depend on whether the incident light has left-handed circularly polarization (LCP) or right-handed circularly polarization (RCP). Therefore, it is possible to achieve plasmonic chiral metamaterials with strongly enhanced chiroptical effects and compact size. [1,[16][17][18] A large number of plasmonic chiral metamaterials with different configurations have been demonstrated including gammadions, [19] helixes, [10] and self-assembled chiral super structures. [20] The building blocks for solid-state chiral metamaterials on substrates are either inherently chiral plasmonic nanostructures [21][22][23][24] or anisotropic achiral plasmonic nanostructures stacked into chiral structures with site-specific twists. [25][26][27][28] Fabrication of these building blocks often requires sophisticated lithographic techniques such as e-beam lithography and focused ion-beam lithography to define features at the nanoscale for targeted performances. Moreover, multistep precise alignments are needed to fabricate the metamaterials consisted of the stacked building blocks. The structural and spatial precision for the building blocks is often below 50 nm for the metamaterials working in the visible and near-infrared regimes, limiting the fabrication throughput, scalability, and reproducibility. In addition, new design and fabrication of the samples are needed to tune the chiroptical responses.Herein, we report a new type of chiral metamaterials, known as moiré chiral metamaterials (MCMs), consisted of two layers of identical achiral Au nanohole arrays stacked into moiré patterns. In contrast to the previously reported plasmonic chiral metamaterials based on local structural chirality or site-specific twisting of anisotropic components, the optical chirality of MCMs is originated from relative in-plane rotation between the lattice directions of the two identical achiral layers. The chiroptical responses of the moiré chiral metamaterials can be precisely tuned by the in-plane rotation between the two layers of nanohole arrays. Through experimental and theoretical studies, we reveal mechanism behind the chiroptical effects in the moiré chiral metamaterials. Furthermore, we apply the moiré chiral metamaterials to achieve label-free enantiodiscrimination of biomolecules and drug molecules at the picogram level. With their ultrathin thickness (≈70 nm, which is only ≈1/10 of the operation wavelength), strong chirality, and high tunability, Plasmonic chiral metamaterials are promising for applications in chiral sensors and photonic devices due to their strong optical chirality and lightmatter interactions at the subwavelength scale. However, most of current plasmonic chiral metamaterials rely on local structural chirality or site-specific symmetry breaking, which has limited their optica...

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“…The SERS phenomenon is based on light excitation of surface plasmon resonances, which induces an enhanced electromagnetic field at noble‐metal nanostructures . Particularly, enormous electromagnetic fields enhancement can be found in sub‐10 nm gaps and at sharp tips, typically referred to as “hot spots.” Once target molecules are placed inside these hot spots, their Raman signals would be dramatically amplified …”

Section: Assignment Of Bands In Sers Spectra Of Aβ Oligomers N = Strmentioning

confidence: 99%

Lotus Seedpod Inspired SERS Substrates: A Novel Platform Consisting of 3D Sub‐10 nm Annular Hot Spots for Ultrasensitive SERS Detection

Jin

et al. 2018

Advanced Optical Materials

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A novel lotus seedpod (LSP) like array substrate with tailorable annular nanogaps is reported for surface‐enhanced Raman spectroscopy (SERS). High SERS activity with excellent Raman signal reproducibility is achieved for molecular detection. Finite‐different time‐domain simulation suggests that sub‐10 nm annular nanogaps formed in the LSP array contribute significantly to the electromagnetic field enhancement for SERS measurements. The SERS substrate presents a detection limit as low as 10−12m along with a relative standard deviation as small as 4.1−8.0% in the detection of rhodamine 6G (R6G). Moreover, the linear correlation between Raman intensity and the concentration of R6G indicates the capability of the substrate for quantitative SERS analyses. As a typical example, the SERS substrate is successfully applied to detecting the α‐helical structure of amyloid‐β oligomers at a low concentration of 0.1 × 10−6m, which will be promising for label‐free detection of Alzheimer's disease in its earliest, presymptomatic, and most treatable stages. The as‐fabricated LSP array substrates therefore hold exciting potentials toward SERS‐based chemical and biomedical detections.

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3D Cross‐Point Plasmonic Nanoarchitectures Containing Dense and Regular Hot Spots for Surface‐Enhanced Raman Spectroscopy Analysis

Cited by 187 publications

References 60 publications

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

Moiré Chiral Metamaterials

Lotus Seedpod Inspired SERS Substrates: A Novel Platform Consisting of 3D Sub‐10 nm Annular Hot Spots for Ultrasensitive SERS Detection

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