3D Bioprinting of Collagen-based Microfluidics for Engineering Fully-biologic Tissue Systems
Daniel J. Shiwarski,
Andrew R. Hudson,
Joshua W. Tashman
et al.
Abstract:Microfluidic and organ-on-a-chip devices have improved the physiologic and translational relevance of in vitro systems in applications ranging from disease modeling to drug discovery and pharmacology. However, current manufacturing approaches have limitations in terms of materials used, non-native mechanical properties, patterning of extracellular matrix (ECM) and cells in 3D, and remodeling by cells into more complex tissues. We present a method to 3D bioprint ECM and cells into microfluidic collagen-based hi… Show more
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