3D bioprinting: Materials, processes, and applications

Bartolo, Paulo Jorge Da Silva; Malshe, Ajay P.; Ferraris, Eleonora; Koç, Bahattin

doi:10.1016/j.cirp.2022.06.001

Cited by 26 publications

(39 citation statements)

References 226 publications

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“…Moreover, glycols, such as polypropylene glycol (PPG), consisting of a mixture of polymers that vary in chain lengths and its monomer propylene glycol (PG) (1,2-propanediol), make up a large proportion of the overall emissions. PPG is regularly used as a component of SLA printing resins, 47 but in this case, it is more likely to be a polymerization product of PG resulting from the hydrolysis of HPMA in PG and methacrylic acid. The detection of PG was also reported by Zhang et al, 24 who measured PG emissions during 3D printing and associated it with both the bulk resin and the photopolymerization process.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications

Pham

Wojnowski

Beauchamp

2022

Chem. Res. Toxicol.

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Stereolithography three-dimensional printing is used increasingly in biomedical applications to create components for use in healthcare and therapy. The exposure of patients to volatile organic compounds (VOCs) emitted from cured resins represents an element of concern in such applications. Here, we investigate the biocompatibility in relation to inhalation exposure of volatile emissions of three different cured commercial resins for use in printing a mouthpiece adapter for sampling exhaled breath. VOC emission rates were estimated based on direct analysis using a microchamber/thermal extractor coupled to a proton transfer reaction-mass spectrometer. Complementary analyses using comprehensive gas chromatography−mass spectrometry aided compound identification. Major VOCs emitted from the cured resins were associated with polymerization agents, additives, and postprocessing procedures and included alcohols, aldehydes, ketones, hydrocarbons, esters, and terpenes. Total VOC emissions from cubes printed using the general-purpose resin were approximately an order of magnitude higher than those of the cubes printed using resins dedicated to biomedical applications at the respective test temperatures (40 and 25 °C). Daily inhalation exposures were estimated and compared with daily tolerable intake levels or standard thresholds of toxicological concerns. The two resins intended for biomedical applications were deemed suitable for fabricating an adapter mouthpiece for use in breath research. The general-purpose resin was unsuitable, with daily inhalation exposures for breath sampling applications at 40 °C estimated at 310 μg day −1 for propylene glycol (tolerable intake (TI) limit of 190 μg day −1 ) and 1254 μg day −1 for methyl acrylate (TI of 43 μg day −1 ).

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications

Pham

Wojnowski

Beauchamp

2022

Chem. Res. Toxicol.

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“…The bioinks with shear-thinning features are usually employed for extrusion-based techniques as these properties facilitate the extrusion of bioink from the printing nozzle . Shear-thinning, which occurs in non-Newtonian fluids, can be described as a drop of viscosity with increasing shear rate, and it is an important parameter for decreasing shear stress . Most of the above-mentioned biomaterials with a wide range of viscosities (30 to 60 × 10 7 mPa·s) apply to extrusion-based bioprinting methodologies. , However, the use of low viscous biomaterials with this method causes decreases in the scaffold integrity.…”

Section: Key Parametersmentioning

confidence: 99%

Applications of 3D Bioprinting Technology to Brain Cells and Brain Tumor Models: Special Emphasis to Glioblastoma

Ozbek,

Saybasili,

Ulgen

2024

ACS Biomater. Sci. Eng.

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Primary brain tumor is one of the most fatal diseases. The most malignant type among them, glioblastoma (GBM), has low survival rates. Standard treatments reduce the life quality of patients due to serious side effects. Tumor aggressiveness and the unique structure of the brain render the removal of tumors and the development of new therapies challenging. To elucidate the characteristics of brain tumors and examine their response to drugs, realistic systems that mimic the tumor environment and cellular crosstalk are desperately needed. In the past decade, 3D GBM models have been presented as excellent platforms as they allowed the investigation of the phenotypes of GBM and testing innovative therapeutic strategies. In that scope, 3D bioprinting technology offers utilities such as fabricating realistic 3D bioprinted structures in a layer-by-layer manner and precisely controlled deposition of materials and cells, and they can be integrated with other technologies like the microfluidics approach. This Review covers studies that investigated 3D bioprinted brain tumor models, especially GBM using 3D bioprinting techniques and essential parameters that affect the result and quality of the study like frequently used cells, the type and physical characteristics of hydrogel, bioprinting conditions, cross-linking methods, and characterization techniques.

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“…Laser-assisted bio-printing (LAB) is a variation on direct-write and laser-induced forward transfer techniques (refer to Figure 5 c) [ 155 ]. A variety of methods, including laser-guided direct-writing (LGDW), laser-induced forward transfer (LIFT), and modified laser-induced forward transfer (modified-LIFT) processes, are used in laser-assisted bioprinting to deposit cell solutions with high cell concentrations at high speeds (about ≥10 m/s) [ 156 ]. Among all the LAB bio-printing methods, laser-induced forward transfer (LIFT) was initially created for writing on metals and has been successfully used to bio-print DNA or organ cells [ 157 ].…”

Section: Classification Of 3d Bio-printingmentioning

confidence: 99%

Recent Developments in 3D Bio-Printing and Its Biomedical Applications

Assad

Assad²,

Kumar³

2023

Pharmaceutics

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The fast-developing field of 3D bio-printing has been extensively used to improve the usability and performance of scaffolds filled with cells. Over the last few decades, a variety of tissues and organs including skin, blood vessels, and hearts, etc., have all been produced in large quantities via 3D bio-printing. These tissues and organs are not only able to serve as building blocks for the ultimate goal of repair and regeneration, but they can also be utilized as in vitro models for pharmacokinetics, drug screening, and other purposes. To further 3D-printing uses in tissue engineering, research on novel, suitable biomaterials with quick cross-linking capabilities is a prerequisite. A wider variety of acceptable 3D-printed materials are still needed, as well as better printing resolution (particularly at the nanoscale range), speed, and biomaterial compatibility. The aim of this study is to provide expertise in the most prevalent and new biomaterials used in 3D bio-printing as well as an introduction to the associated approaches that are frequently considered by researchers. Furthermore, an effort has been made to convey the most pertinent implementations of 3D bio-printing processes, such as tissue regeneration, etc., by providing the most significant research together with a comprehensive list of material selection guidelines, constraints, and future prospects.

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3D bioprinting: Materials, processes, and applications

Cited by 26 publications

References 226 publications

Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications

Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications

Applications of 3D Bioprinting Technology to Brain Cells and Brain Tumor Models: Special Emphasis to Glioblastoma

Recent Developments in 3D Bio-Printing and Its Biomedical Applications

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