3D bioprinting for lung and tracheal tissue engineering: Criteria, advances, challenges, and future directions

Mahfouzi, Seyed Hossein; Tali, Seyed Hamid Safiabadi; Amoabediny, Ghassem

doi:10.1016/j.bprint.2020.e00124

Cited by 39 publications

(25 citation statements)

References 140 publications

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“…2 Simplified illustrations of 3D bioprinting types: A inkjet bioprinting, B laser-assisted printing, C extrusion bioprinting, and D Stereolithographic printing. Recreated from Mahfouzi et al ( 29 ) …”

Section: Bioprinting Techniques and Approachesmentioning

confidence: 99%

“…There are several other requirements for bioprinters to properly print lungs and alveoli, for example. They must support various types of multiple nozzles for printing different parts of the lungs at the same time, e.g., one of the nozzles will print supports for the structure of the lungs and the other nozzles will have different bioprinting types to print micro to nano alveoli resolution ( 29 ). Additionally, the printing speed must be optimal to protect both the cells and the bioinks while we are printing, as extended printing procedures may impair cell viability ( 30 ).…”

Section: Bioprinting Techniques and Approachesmentioning

confidence: 99%

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3D Bioprinting of Human Hollow Organs

Panja¹,

Maji²,

Choudhuri³

et al. 2022

AAPS PharmSciTech

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3D bioprinting is a rapidly evolving technique that has been found to have extensive applications in disease research, tissue engineering, and regenerative medicine. 3D bioprinting might be a solution to global organ shortages and the growing aversion to testing cell patterning for novel tissue fabrication and building superior disease models. It has the unrivaled capability of layer-by-layer deposition using different types of biomaterials, stem cells, and biomolecules with a perfectly regulated spatial distribution. The tissue regeneration of hollow organs has always been a challenge for medical science because of the complexities of their cell structures. In this mini review, we will address the status of the science behind tissue engineering and 3D bioprinting of epithelialized tubular hollow organs. This review will also cover the current challenges and prospects, as well as the application of these complicated 3D-printed organs. Graphical abstract

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Section: Bioprinting Techniques and Approachesmentioning

confidence: 99%

Section: Bioprinting Techniques and Approachesmentioning

confidence: 99%

3D Bioprinting of Human Hollow Organs

Panja¹,

Maji²,

Choudhuri³

et al. 2022

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…Limitations for organ donation include finding the right donated organ according to age, gender, geographic region, blood group, immune responses, and organ toxicity; taking various immune suppressant medications and treatments before organ donation; long recovery times; limited available; and so much more. 4 It has been estimated that patients frequently wait for an organ for transplantation for around two years; while other statistics indicate that 20% of people do not survive the first year after organ transplant surgery. Unsurprisingly, over the last two years, some countries have reported a 50% reduction in organ transplantation surgeries due to the COVID-19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

Shokrani¹,

Shokrani²,

Sajadi³

et al. 2022

IJN

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One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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“…Presently, this technology has application mainly in the area of medical surgery, where it is used to transplant synthetically printed tissues into patients [ 2 ]. Transplanted tissues are usually printed according to a patient’s cells [ 3 ]. Sometimes, they are printed according to donors’ cells [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Patent Eligibility of 3D Bioprinting: Towards a New Version of Living Inventions’ Patentability

Althabhawi

Zainol

2022

Biomolecules

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A combination of 3D printing techniques and synthetic biology, 3D bioprinting is a promising field. It is expected that 3D bioprinting technologies will have applications across an array of fields, spanning biotechnology, medical surgery and the pharmaceutical industry. Nonetheless, the progress of these technologies could be hindered, unless there is adequate and effective protection for related applications. In this article, the authors examine the patent eligibility of 3D bioprinting technologies. This issue raises concern given that existing patent systems are generally averse to nature-derived inventions and many of them exclude products of nature or discoveries from patentability. This qualitative study analyses the current patent systems in key jurisdictions, particularly, the U.S. and the EU, and their applicability, as well as effectiveness, in the context of 3D bioprinting. The study argues that the main reason for the apathy of existing patent systems towards bio-inventions is that they were designed to deal with mechanical inventions. It suggests an innovation framework that encompasses both mechanical and biological inventions to cater adequately to emerging technologies.

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3D bioprinting for lung and tracheal tissue engineering: Criteria, advances, challenges, and future directions

Cited by 39 publications

References 140 publications

3D Bioprinting of Human Hollow Organs

3D Bioprinting of Human Hollow Organs

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

The Patent Eligibility of 3D Bioprinting: Towards a New Version of Living Inventions’ Patentability

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