Abstract:Loss of β cells leads to diabetes. α cells are refractory to spontaneous conversion to β cells, but a small percentage are reprogrammed to β cells with acute β cell loss. β cell heterogeneity and identification of β cell subpopulations and their transcriptomic profiles have been reported. However, α cell subpopulations in the human islet have not been clearly defined yet. Moreover, whether specific human α cell subpopulations can potentially evolve into β cells is unknown. Here, we integrated scRNA- and snRNA-… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.