35 Hepatitis E as a Zoonosis and the Relevance for Liver Transplant Recipients

Pischke, Sven; Baechlein, Christine; Suneetha, Pothakamuri Venkata; Raupach, R.; Schlué, Jérôme; Becker, Jaime; Heim, Albert; Strassburg, CP; Manns, Michael P.; Grummer, B.; Wedemeyer, Heiner

doi:10.1016/s0168-8278(09)60037-4

Cited by 3 publications

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“…In addition, a study from Argentina also showed a raised HEV‐IgG‐seroprevalence in HIV‐patients (6.6%) when compared to healthy controls (1.8%) [6]. In this study, we found a seroprevalence of 5% which seemed to be slightly higher than our experience with healthy employees and blood donors where anti‐HEV IgG antibodies were found in one of 108 subjects studied [7]. The reason for the slightly higher anti‐HEV seroprevalence in HIV‐infected patients is unknown.…”

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confidence: 43%

“…Importantly, HEV infection can also be acquired as a zoonosis because HEV genotype 3 is present in various animal species including swine, rats and cats [10,11]. We recently described two cases of chronic hepatitis E in liver transplant recipients; both patients were infected with HEV genotype 3 [7]. One may speculate that viral factors could contribute to the course of HEV infection, i.e.…”

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confidence: 99%

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Hepatitis E in HIV‐positive patients in a low‐endemic country

Pischke

Urbanek³

et al. 2010

Journal of Viral Hepatitis

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confidence: 43%

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confidence: 99%

Hepatitis E in HIV‐positive patients in a low‐endemic country

Pischke

Urbanek³

et al. 2010

Journal of Viral Hepatitis

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“…15 A study in Argentina also showed higher anti-HEV prevalence in HIV-infected patients (6.6%) compared to healthy controls (1.8%), 14 as did a study by Pischke et al (5% vs. 1%, respectively). 19,29 Given the low general or control population prevalence in the settings, it may be possible that an association is not evident or detected in areas with moderate-to-high prevalence of HEV. It may also be possible that divergent results are due to differences in the accuracy of different diagnostic assays.…”

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confidence: 99%

Hepatitis E virus infection in patients infected with human immunodeficiency virus in an endemic area in Iran

et al. 2013

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Some studies have suggested that hepatitis E virus is more frequent in human immunodeficiency virus (HIV) patients and can progress to chronic infection. We aimed to determine the prevalence of hepatitis E virus antibodies and RNA in a series of 100 HIV-infected patients in Tehran, Iran, with comparison to 52 healthy HIV, hepatitis B and C-negative blood donors as controls. HIV-infected patients were also tested for hepatitis E virus-RNA. Among the HIV-infected patients, 10% had antibodies to hepatitis E virus - a finding not significantly different from the uninfected controls (11.5%). No HIV-infected patients had hepatitis E virus IgM antibodies nor did any have detectable hepatitis E virus-RNA. We found no associations between anti-hepatitis E virus IgG-seropositivity and age, sex, route of HIV acquisition, aminotransferases levels, CD4, antiretroviral therapy, hepatitis B virus and hepatitis C virus co-infection. Hepatitis E virus is relatively prevalent in our HIV-infected patients, although without evidence of chronic infection and no more common than among HIV-negative controls or the general population. For the present, we do not recommend routine screening for hepatitis E virus infection in HIV-infected patients in our moderately endemic region.

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“…The possible common routs of human infection with HEV are faecal–oral spreading, drinking contaminated water and ingesting undercooked meat (Meng et al., 1997). Also, HE was recorded in liver transplanted patients with graft hepatitis (Pischke et al., 2009). The serology, RT‐PCR and histopathology investigation of liver could confirm the HEV infection (Halbur et al., 2001).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis E Virus in Humans and Geographically Matched Food Animals in Egypt

El‐Tras

Tayel

El-Kady³

2012

Zoonoses and Public Health

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The aim of current study was to investigate the epidemiology of Hepatitis E virus (HEV) in humans and geographically matched food animals as a novel zoonotic assessment in Egypt. Blood samples were collected from patients who had a history of jaundice and attended to fever and general hospitals. Animal blood samples were collected from cows, buffaloes, sheep and goats convenient to HEV seropositive humans. Enzyme Immuno Assay (EIA) protocol was used to determine IgG anti-HEV. Sex and pregnancy were investigated as potential risk factors for HEV infection. Of 134 examined humans, 51 (38.1%) were positive for IgG anti-HEV. The males showed 26.8% seropositivity while the recorded female seropositivity was 50.8%, with a significant difference at P = 0.005, Odds Ratio (OR) = 0.35 at 95% confidence interval (CI): 0.17-0.73. There was a significant difference at P = 0.02 between seropositivity in pregnant (25%) and non-pregnant women (59.6%); OR was 0.23 (95% CI: 0.06-0.81). Anorexia was the most common symptom whereas paraesthesia and back pain were the least within icteric seropositive HEV humans. Hepatitis E virus seropositivity was recorded in 21.6%, 14%, 4.4% and 9.4% from examined cows, buffaloes, sheep and goats, respectively. The infected food animals were convenient to positive HEV humans who may declare the epidemiological picture of potential zoonotic HEV.

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35 Hepatitis E as a Zoonosis and the Relevance for Liver Transplant Recipients

Cited by 3 publications

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Hepatitis E in HIV‐positive patients in a low‐endemic country

Hepatitis E in HIV‐positive patients in a low‐endemic country

Hepatitis E virus infection in patients infected with human immunodeficiency virus in an endemic area in Iran

Seroprevalence of Hepatitis E Virus in Humans and Geographically Matched Food Animals in Egypt

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