Abstract:Introduction:We have demonstrated the therapeutic potential of human polyclonal and antigen-specific CAR-modified CD8 + Tregs cell therapy to prevent allogeneic human skin transplantation rejection and xenogeneic GvHD in humanized NSG mice (Bézie et al., Front Immunol.2017, Blood Adv.2019). However, their potential has never been evaluated in a clinical trial. We are thus preparing the launch of a phase I/IIa human clinical trial using polyclonal CD8 + Tregs cell therapy in living donors kidney transplant pati… Show more
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