2021
DOI: 10.1093/asj/sjab236
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Abstract: Background Androgenetic alopecia (AGA) is a common disorder in male and female patients that may benefit from the use of platelet-rich plasma. Objectives To compare the safety, efficacy, and satisfaction of a lower or higher number of platelets over 6 months. Methods A prospective randomized, double-blinded, placebo, paralleled group, half-scalp IRB study amo… Show more

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Cited by 8 publications
(6 citation statements)
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“…The data that were available for analyses came from 5 of the 25 studies. These studies were the randomized placebo‐controlled trials by Alves and Grimalt 26 , Dubin et al 27 Gressenberger et al 28 Sasaki 29 and Zhou et al 30 ; the authors investigated the impact of PRP monotherapy on change in total hair density (hairs/cm 2 ) 6 months after baseline. Given that Sasaki (2021) had conducted two trials concurrently, data from six placebo arms were available for both the one‐arm meta‐analyses and multivariable meta‐regression; there were a total of 60 patients across the six arms.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The data that were available for analyses came from 5 of the 25 studies. These studies were the randomized placebo‐controlled trials by Alves and Grimalt 26 , Dubin et al 27 Gressenberger et al 28 Sasaki 29 and Zhou et al 30 ; the authors investigated the impact of PRP monotherapy on change in total hair density (hairs/cm 2 ) 6 months after baseline. Given that Sasaki (2021) had conducted two trials concurrently, data from six placebo arms were available for both the one‐arm meta‐analyses and multivariable meta‐regression; there were a total of 60 patients across the six arms.…”
Section: Resultsmentioning
confidence: 99%
“…Data from the six placebo arms across Alves and Grimalt 26 Dubin et al 27 Gressenberger et al 28 Sasaki 29 and Zhou et al 30 were used to conduct one‐arm meta‐analyses on outcome data from the split‐scalp and whole‐head subgroups; Figure 4 presents results of our subgroup analyses through a forest plot.…”
Section: Resultsmentioning
confidence: 99%
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“…Higher numbers of platelets have a greater effect than lower numbers of platelets in terms of hair density, follicle diameter, and terminal hair density. 41 In AGA, action of dihydrotestosterone on dermal papilla cells suppressed canonical WNT signaling, resulting in defective hair growth and retarding hair cycling. PRP promoting hair growth by activating WNT/β-Catenin signaling lead to proliferation and differentiation of hair follicle cells and triggering new hair cycle.…”
Section: Use Of Platelet Rich Plasma In Hair Disordersmentioning
confidence: 99%
“…A recent paper by Dr Gordon Sasaki looked at the effect on alopecia of 2 different platelet concentrations of platelet-rich plasma (PRP) compared to placebo. 1 Although improvement was associated with the higher concentration, statistical significance was not reached. As the main variable, and the basis of this study, platelet concentration deserves a closer look.…”
mentioning
confidence: 95%