Serum or plasma ferritin concentration as an index of iron deficiency and overload

Garcı́a-Casal, Marı́a Nieves; Pasricha, Sant‐Rayn; Martinez, Ricardo X; Lopez-Perez, Lucero; Peña‐Rosas, Juan Pablo

doi:10.1002/14651858.cd011817.pub2

Cited by 25 publications

(14 citation statements)

References 314 publications

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“…Iron is an essential nutrient for the body and has potential toxic effects. SF is a tissue protein that stores iron [ 26 ]. Ferritin is widely recognized as a non-specific acute-phase response and inflammation marker, reflecting the degree of oxidative stress and inflammation in vivo.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study

et al. 2022

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Background Serum ferritin (SF), as an acute-phase response protein, is used to reflect the degree of oxidative stress and systemic inflammatory responses. This study was designed to assess the effect of elevated SF levels on the severity of acute pancreatitis (AP). Methods From January 2013 to December 2020, 200 consecutive patients with AP were retrospectively reviewed to analyze the relationships among the etiologies of pancreatitis, the severity of the disease and SF levels. The receiver operating characteristic (ROC) curve and logistic regression analysis were used to assess whether elevated SF levels could predict the onset of organ failure in AP. Results 92 (46%) had high SF levels (> 275 ng/ml). SF levels were not associated with the etiology of AP disease. Among patients with high SF levels, there was a significant increase in the proportion of patients with severe AP (23.1% vs. 76.9%) and a higher proportion of systemic inflammatory response scores (25.9% vs. 44.6%) in comparison to patients with normal SF levels. The area under the ROC curve for SF in predicting persistent organ failure was 0.812 [95% confidence interval 0.721–0.904]. Conclusions F concentrations were positively correlated with the severity of AP, and quantitative assessment of SF can predict disease severity and organ failure in patients with AP.

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Section: Discussionmentioning

confidence: 99%

Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study

et al. 2022

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“…Therefore, serum and plasma ferritin concentrations are the most widely used indicators of systemic iron levels. 201 For instance, serum ferritin levels have been used to diagnose iron-deficient heart failure with reduced ejection fraction. 202 The WHO recommends serum or plasma ferritin concentrations as biomarkers for assessing iron status in individuals and populations.…”

Section: Targeting Ferroptosis To Diagnose or Treat Age-related Ortho...mentioning

confidence: 99%

“… 151 , 152 Notably, a Cochrane meta-analysis revealed that blood ferritin concentration is a very sensitive indicator, with a detection threshold of 30 μg·L −1 , and is a very specific marker of iron deficiency and that a high ferritin concentration is a sensitive indicator of iron overload; however, the reliability of these findings is low. 201 Moreover, ferritin is an acute-phase protein, and ferritin levels are increased during inflammation and infection. The applicability of current WHO blood ferritin concentration thresholds to different age groups or physiological conditions is still limited.…”

Section: Targeting Ferroptosis To Diagnose or Treat Age-related Ortho...mentioning

confidence: 99%

Fighting age-related orthopedic diseases: focusing on ferroptosis

Xie

et al. 2023

Bone Res

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Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthesis of compounds with antioxidant activities, including glutathione. In the past 10 years, increasing evidence has indicated a potentially strong relationship between ferroptosis and the onset and progression of age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Therefore, in-depth knowledge of the regulatory mechanisms of ferroptosis in age-related orthopedic diseases may help improve disease treatment and prevention. This review provides an overview of recent research on ferroptosis and its influences on bone and cartilage homeostasis. It begins with a brief overview of systemic iron metabolism and ferroptosis, particularly the potential mechanisms of ferroptosis. It presents a discussion on the role of ferroptosis in age-related orthopedic diseases, including promotion of bone loss and cartilage degradation and the inhibition of osteogenesis. Finally, it focuses on the future of targeting ferroptosis to treat age-related orthopedic diseases with the intention of inspiring further clinical research and the development of therapeutic strategies.

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“…Though serum ferritin level is commonly used to screen neonates for iron deficiency, 43 it is not well validated in extremely preterm neonates. A more recent method used to assess iron stores is the RET-He, which measures the hemoglobin within reticulocytes.…”

Section: Developing Practical Ways To Identify Neonatal Iron Deficiencymentioning

confidence: 99%

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

Christensen¹,

Bahr²

2022

Newborn

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Iron deficiency can exist at birth. Even if iron is sufficient at birth, deficiency can develop during the neonatal period, or during infancy, or during childhood. Iron deficiency can exist despite a normal hematocrit and a normal blood hemoglobin concentration, because anemia is a very late manifestation of iron deficiency. It is likely that adverse neurodevelopmental consequences occur during perinatal biochemical iron deficiency, despite a normal hematocrit and hemoglobin. Consequently, measuring those parameters is a very insensitive method for perinatal iron deficiency screening. This review focuses on potentially better practices for diagnosing perinatal iron deficiency, including recent advances in understanding the pathogenesis of this condition, and also on practical means of treatment, and on global rewards of so doing.

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Serum or plasma ferritin concentration as an index of iron deficiency and overload

Cited by 25 publications

References 314 publications

Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study

Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study

Fighting age-related orthopedic diseases: focusing on ferroptosis

Iron Deficiency in Newborn Infants: Global Rewards for Recognizing and Treating This Silent Malady

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