2021
DOI: 10.1016/j.nmni.2021.100901
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Abstract: Background Convalescent plasma therapy (CPT) is one of the well-known therapeutic protocols for treating infectious diseases that do not have special treatment nor vaccine. Several documents confirm the clinical efficacy of this therapy for treating bacterial and viral infections. Methods A comprehensive systematic search was conducted by August 2020 using global databases including PubMed, Scopus, Embase, Cochrane library, Google scholar, medRxiv, and bioRxiv. The Joan… Show more

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Cited by 5 publications
(5 citation statements)
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“…The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is reported in Figure 1 . After the full texts were scrutinized against the inclusion and exclusion criteria, 29 SRs were included in the umbrella review [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ] and 23 SRs were excluded [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is reported in Figure 1 . After the full texts were scrutinized against the inclusion and exclusion criteria, 29 SRs were included in the umbrella review [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ] and 23 SRs were excluded [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , …”
Section: Resultsmentioning
confidence: 99%
“…Of the 29 SRs included in the overview, 26 were focused exclusively on COVID-19 [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], while three were focused on respiratory pandemics and on beta coronaviruses infections [ 10 , 19 , 30 ]. Two SRs [ 17 , 22 ] were a subgroup analysis of other reviews [ 16 , 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…We also pooled the data in significant heterogeneity cases using the DerSimonial and Laird random effects model. Furthermore, publication bias was measured based on Begg's p value, Egger's p value, and asymmetry of funnel plot [ 48 ].…”
Section: Methodsmentioning
confidence: 99%
“…Immunotherapeutic approaches are one of the therapeutic modalities that have received a lot of attention. Convalescent plasma therapy (CPT) or monoclonal antibodies (MABs) based therapy is an efficient and reliable immunotherapeutic approach that aims to boost patients’ immune systems and protect them from viral infection [ 20 , 21 ]. Among a plethora of therapeutic options, CPT has shown real potential in the treatment of patients with COVID-19.…”
Section: Introductionmentioning
confidence: 99%
“…CPT relies on a high titer value of neutralizing antibodies (NABs) which are usually present in the plasma of recovered patients. NABs are transferred into recently infected patients with SARS-CoV-2, which helps in combating viral multiplication [ [21] , [22] , [23] ]. CPT has been employed in various viral outbreaks, namely SARS, MERS, Ebola, and H1N1 influenza [ [24] , [25] , [26] , [27] , [28] ].…”
Section: Introductionmentioning
confidence: 99%