Increased risk of asthma at age 10 years for children sensitized to multiple allergens

Havstad, Suzanne; Sitarik, Alexandra R.; Kim, Hae Jin; Zoratti, Edward M.; Ownby, Dennis R.; Johnson, Christine Cole; Wegienka, Ganesa

doi:10.1016/j.anai.2021.04.028

Cited by 5 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in agreement with the model by Custovic et al in which sensitised children formed different clusters having variable associations with asthma 28,29 . Similar findings have also been described in two other studies 6,13 . Furthermore, they support arguments against the traditional atopic march theory described in another study 29 …”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, allergic sensitisation is a risk factor for asthma and the modified Asthma Predictive Index includes allergic sensitisation in its criteria 12 . Multiple sensitisation of allergens in early life increases the risk of developing asthma at a later age 7,11,13 …”

Section: Introductionmentioning

confidence: 99%

“…12 Multiple sensitisation of allergens in early life increases the risk of developing asthma at a later age. 7,11,13 Sensitisation to aeroallergens can also affect the severity of asthma. 14 The Swedish BAMSE longitudinal birth cohort study collected blood samples from approximately 2500 children aged 16 years reported that allergic sensitisation was associated with increased expired nitrous oxide levels regardless of whether the child had allergic rhinitis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Allergic sensitisation did not affect bronchial hyper‐responsiveness in children without respiratory tract symptoms

2021

View full text Add to dashboard Cite

Approximately 34%-51% of children living in the Western world have allergic sensitisation. [1][2][3] This prevalence is seemingly related to their standard of living 2 and has been strongly associated with rhinitis. 3 Moreover, predisposition to produce specific immunoglobulin E antibodies to environmental allergens is linked to airway inflammation and causes bronchial hyperresponsiveness (BHR). 4 Allergic sensitisation increases the prevalence of BHR in adults and children, 5,6 and one study reported particular associations between sensitisation to animal allergens. 5 Polysensitisation in early childhood predicts lower lung function in later life. 7

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Allergic sensitisation did not affect bronchial hyper‐responsiveness in children without respiratory tract symptoms

2021

View full text Add to dashboard Cite

show abstract

“…There have been some reports about multiple sensitizations to food allergens and subsequent allergic disease. 11,12 However, to the best of our knowledge, there are currently no reports analyzing the clinical course and remission of food allergy using LCA.…”

mentioning

confidence: 99%

Phenotyping of immediate‐type food allergies based on 10 years of research: A latent class analysis

Takahashi

Yanagida

Itonaga

et al. 2022

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Food allergy is a disease with diversity and variable natural history.Most patients acquire tolerance as they mature, whereas some patients have persistent symptoms. For example, 70%-80% of patients with allergy to hen's egg naturally acquire tolerance by the age of 6 years. 1 In addition, some patients may have food allergy to two or more antigens concomitantly. Among atopic disease patients, 57% reacted to two or three foods in oral food challenges (OFCs). 2 Patients can develop symptoms from accidental ingestion, 3 and their

show abstract

“…The risk of current AD was independent of the sensitization pattern but remained raised for children with any sensitization. No differences were found in spirometry parameters [29].…”

Section: Allergic Polysensitizationmentioning

confidence: 73%

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

et al. 2022

View full text Add to dashboard Cite

Recent evidence showed that the postulated linear progression of the atopic march, from atopic dermatitis to food and respiratory allergies, does not capture the heterogeneity of allergic phenotypes, which are influenced by complex interactions between environmental, genetic, and psychosocial factors. Indeed, multiple atopic trajectories are possible in addition to the classic atopic march. Nevertheless, atopic dermatitis is often the first manifestation of an atopic march. Improved understanding of atopic dermatitis pathogenesis is warranted as this could represent a turning point in the prevention of atopic march. In this review, we outline the recent findings on the pathogenetic mechanisms leading to atopic dermatitis that could be targeted by intervention strategies for the prevention of atopic march.

show abstract

Increased risk of asthma at age 10 years for children sensitized to multiple allergens

Cited by 5 publications

References 16 publications

Allergic sensitisation did not affect bronchial hyper‐responsiveness in children without respiratory tract symptoms

Allergic sensitisation did not affect bronchial hyper‐responsiveness in children without respiratory tract symptoms

Phenotyping of immediate‐type food allergies based on 10 years of research: A latent class analysis

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

Contact Info

Product

Resources

About