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Cited by 37 publications
(14 citation statements)
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“…Patients treated with PDE5 inhibitors display high discontinuation rates due to adverse events or inefficacy and, thus, research on novel ED treatment is imperative (Burnett and Hellstrom, 2012). Promising single or combination treatment modalities that may comprise growth factor therapy, stem cell therapy, or even gene therapy and tissue engineering may make their way through the clinical pipeline (Poulios et al, 2021;Raheem et al, 2021). Consequently, studies comparing the efficacy and safety of such treatment strategies in the form of monotherapy or combination therapy with PDE5 inhibitors are mandatory.…”
Section: Discussionmentioning
confidence: 99%
“…Patients treated with PDE5 inhibitors display high discontinuation rates due to adverse events or inefficacy and, thus, research on novel ED treatment is imperative (Burnett and Hellstrom, 2012). Promising single or combination treatment modalities that may comprise growth factor therapy, stem cell therapy, or even gene therapy and tissue engineering may make their way through the clinical pipeline (Poulios et al, 2021;Raheem et al, 2021). Consequently, studies comparing the efficacy and safety of such treatment strategies in the form of monotherapy or combination therapy with PDE5 inhibitors are mandatory.…”
Section: Discussionmentioning
confidence: 99%
“…Several preclinical and clinical trials were designated in using autologous PRP for treating ED with a limitation of small groups and short follow-up periods (Chung, 2021;Zaghloul et al, 2021). The main outcome measures for those preclinical trials on ED were erectile function, evaluated with intracavernosal pressure and histopathology of the cavernous tissue (Poulios et al, 2021;Wu et al, 2021).…”
Section: These Augmented Levels Of Platelets Have Been Demonstratedmentioning
confidence: 99%
“…Several preclinical and clinical trials were designated in using autologous PRP for treating ED with a limitation of small groups and short follow‐up periods (Chung, 2021; Zaghloul et al, 2021). The main outcome measures for those preclinical trials on ED were erectile function, evaluated with intracavernosal pressure and histopathology of the cavernous tissue (Poulios et al, 2021; Wu et al, 2021). Besides, the main outcome measures for clinical trials included validated questionnaires as well as penile duplex Doppler ultrasound (Alkandari et al, 2021; Epifanova et al, 2020; Raheem et al, 2021; Scott et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Only one randomized, double blind, placebo-controlled study has been conducted and published to date evaluating the effects of PRP in men with mild and moderate ED ( 34 ). This was conducted by Poulios et al and published in 2021, and is the highest quality study to date of PRP injections in ED.…”
Section: Review Of the Current Evidencementioning
confidence: 99%