The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

Hemamy, Mostafa; Pahlavani, Naseh; Amanollahi, Alireza; Islam, Sheikh Mohammed Shriful; McVicar, Jenna; Askari, Gholamreza; Malekahmadi, Mahsa

doi:10.1186/s12887-021-02631-1

Cited by 14 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vitamin D/Vitamin D receptor does have a protective effect on the nervous system of the brain and also regulates the gut microbiota, and VDR is indirectly linked to neurodevelopmental disorders through the gut brain axis ( Ogbu et al, 2020 ). Vitamin D supplementation has been shown in trials to improve ADHD symptoms ( Hemamy et al, 2021 ). It is also known that vitamin D is a lipid.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

Zhao

Meng²,

Cao³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundAn increasing number of studies have focused on the role of gut microbiota in the treatment of ADHD, but its related molecular mechanisms are not yet clear, and there is still room for development of studies targeting this area. This study analyzes publications from 2012 to 2021 in a comprehensive and multi-faceted visualization, with the aim of grasping the existing research profile and guiding scholars to make more in-depth studies.MethodsThe 1,677 articles and 298 review articles on gut microbiota in ADHD were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, Microsoft Excel 2019, Scimago Graphica, Bibliometrix and Pajek metrics software were used for visualization and analysis of the included literature.ResultsOn August 3, 2022, a total of 1975 English-language articles on gut microbiota in ADHD were retrieved from Web of Science Core Collection (WoSCC) from January 2012 to December 2021, with a steady upward trend in the number of articles published in this field over the decade. The top three countries in terms of the number of articles published are the United States, China, and Spain. Meanwhile, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS CSIC, UNIV OF CALIFORNIA SYSTEM, and UDICE FRENCH RESEARCH UNIV have made significant contributions in this field. In the analysis of the published journals, PLoS One was not only the first in terms of number of articles published but also the most cited. Wang J was the most prolific author and CAPORASO JG ranked first in terms of co-cited authors. In addition, “Diet rapidly and reproducibly alters the human gut microbiome,” published by David LA et al., has the highest citation frequency in this field. The most frequently occurring keyword was “gut microbiota.”ConclusionThe results of this paper clarify the current status of research on gut microbiota in ADHD. Based on the research on the mechanism of gut microbiota in other diseases, there is reason to believe that the exploration of gut microbiota in ADHD must be increasingly mature. And the study speculates that future research may focus on “nutrition supplements,” “lipid metabolism,” and “gut brain axis.” It is imperative to promote a closer international cooperation among scholars in this field.

show abstract

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

Zhao

Meng²,

Cao³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Eine gute Vitamin-D 3 -Versorgung im Mutterleib senkt zudem das Risiko für Kinder, später an chronischen Krankheiten wie Asthma, Allergien [23] und diversen Atemwegsproblemen [24] sowie Autoimmunerkrankungen [25] [44]. Auch gibt es Hinweise aus Interventionsstudien, dass sich eine Magnesiumsupplementation positiv auf Verhaltensfunktionen und psychische Gesundheit von Kindern mit ADHS auswirken kann [45,46]. Es empfiehlt sich daher, im Rahmen einer ADHS-Diagnose auf den Magnesiumstatus zu achten.…”

Section: Mit Vitamin D 3 Die Immunabwehr Stabilisierenunclassified

Gesundheit von Säuglingen und Kindern: Auf den Biofaktorenstatus achten

Birkelbach,

Kisters,

Classen

2023

Zeitschrift für Orthomolekulare Medizin

View full text Add to dashboard Cite

ZusammenfassungEine optimale Versorgung mit Biofaktoren wie Vitaminen, Mineralstoffen und Spurenelementen ist essenziell für die körperliche und geistige Entwicklung von Kindern und Jugendlichen und spielt eine wichtige Rolle in der Prävention von Erkrankungen. Bereits in der Schwangerschaft sollte auf eine ausreichende Versorgung der Mutter mit Vitamin B12 und Vitamin D geachtet werden. Zusammenhänge zwischen Vitamin-D- oder Magnesiummangel und ADHS werden beschrieben.

show abstract

“…Hemamy et al [ 60 ] performed a randomized, double-blind, placebo-controlled clinical trial with 66 children with ADHD to test vitamin D and magnesium. The authors assessed children’s mental health at baseline and at the end of the study using the Strengths and Difficulties Questionnaire (SDQ) and found that co-supplementation for a duration of 8 weeks with 50,000 IU/week of 25-hydroxy-vitamin D3 and 6 mg/kg/day of magnesium significantly reduced emotional problems ( p = 0.001), conduct problems ( p = 0.002), peer problems ( p = 0.001), the prosocial score ( p = 0.007), total difficulties ( p = 0.001), the externalizing score ( p = 0.001), and the internalizing score ( p = 0.001), compared with the placebo group.…”

Section: Nutritional and Dietary Interventionsmentioning

confidence: 99%

Eating Patterns and Dietary Interventions in ADHD: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, affecting ~7% of children and adolescents. Given its adverse health outcomes and high healthcare and societal costs, other treatment options beyond pharmacotherapy have been explored. Case-control studies have shown that dietary patterns may influence the risk of ADHD, and specific dietary interventions have been proposed as coadjuvant treatments in this disorder. These include nutritional supplements, gut microbiome-targeted interventions with biotics, and elimination diets. The purpose of this review is to examine which dietary patterns are most associated with ADHD and to summarize the existing evidence for the clinical use of dietary interventions. The literature showed that non-healthy dietary patterns were positively associated with ADHD, whereas healthy patterns were negatively associated. As for nutritional supplements, only vitamin D and vitamin D + magnesium appeared to improve ADHD symptoms when baseline levels of vitamin D were insufficient/deficient. Regarding biotics, evidence was only found for Lactobacillus rhamnosus GG and for multi-species probiotic supplementation. Elimination diets have scarce evidence and lead to nutritional deficiencies, so caution is advised. Overall, more robust scientific evidence is required for these dietary interventions to be implemented as part of ADHD therapy.

show abstract

The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

Cited by 14 publications

References 43 publications

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021

Gesundheit von Säuglingen und Kindern: Auf den Biofaktorenstatus achten

Eating Patterns and Dietary Interventions in ADHD: A Narrative Review

Contact Info

Product

Resources

About