The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis

Sarı, Hüseyin; Karaketir, Semih; Kumral, Tolgar Lütfı; Akgun, Muhammed Fatih; Gürpınar, Berk; Hancı, Deniz; Berkıten, Güler; Uyar, Yavuz

doi:10.1016/j.amjoto.2021.103010

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, PRF reduces inflammation, suppresses osteoclastogenesis, and increases the expression of various growth factors in mesenchymal cells [ 21 , 22 ]. In the field of otolaryngology, a study conducted by Huseyin et al showed that better results were obtained with the effects of PRF on wound healing in terms of adhesion, infection, bleeding, granulation, and frontal ostium stenosis after endoscopic sinus surgery [ 23 ]. In addition, Cieslik-Bielecka et al introduced the potential application of PRF in esthetic plastic surgery and regenerative medicine for the skin, although PRF is widely used in bone graft surgery, the effectiveness of PRF in increasing implant site or postoperative bone mass and improving implant stability remains controversial [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Guan¹,

Xiao²,

Bai³

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Guan¹,

Xiao²,

Bai³

et al. 2023

Heliyon

View full text Add to dashboard Cite

The impact of submucosal PRP injection on wound healing after endoscopic sinus surgery: a randomized clinical trial

Dinaki,

Grigoriadis,

Vizirianakis

et al. 2024

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose Chronic rhinosinusitis (CRS) is a prevalent chronic disease observed on a global scale. The utilization of endoscopic sinus surgery (ESS) has gained significant recognition as an effective intervention for individuals with CRS and nasal polyps who have not responded to conventional treatments. The need (or not) for revision surgery frequently relies on the promotion of optimal wound healing. The impact of platelet-rich plasma (PRP) on tissue healing has been extensively examined in various surgical fields. Methods The present prospective study involved 30 patients suffering with nasal polyposis who underwent endoscopic sinus surgery. 15 patients were assigned to the PRP group, and 15 patients to the control group. The clinical follow-up of the patients took place at specific intervals, at weeks 1, 2, 3, 4, 8, and 12 after the surgical procedure. The evaluator identified the existence of adhesions, crusting, bleeding, granulation and infection using a visual analogue scale score. The patients also completed the SNOT 22 questionnaire prior to surgery and at each postoperative visit. Results The present study observed a lower incidence of adhesion, infection, hemorrhage and granulation in the PRP group. Furthermore, a statistically significant difference was detected between the groups. Conclusion Based on the findings of the present investigation, it seems that platelet-rich plasma (PRP) is beneficial on wound healing during the early stages following the surgical procedure. The technique is characterized by its limited invasiveness, which contributes to its low risk profile and the achievement of clinically good outcomes.

show abstract

Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial

Javid,

Mourão,

Mello-Machado

et al. 2023

JFB

View full text Add to dashboard Cite

Bone tissue engineering seeks biomaterials that enable cell migration, angiogenesis, matrix deposition, and tissue regeneration. Blood concentrates like platelet-rich fibrin (L-PRF) offer a cost-effective source of cells and growth factors to enhance healing. The present study aimed to evaluate heated serum albumin with liquid PRF (Alb-PRF) and L-PRF clinically and biochemically after placement in dental sockets following mandibular third molar extraction. In a controlled, split-mouth study involving 10 volunteers, 20 extracted molars were treated with either Alb-PRF or L-PRF. Post-extraction, pain, trismus, infection presence, and swelling were measured. The concentrations of different analytes in the surgical sites were also examined. The data were statistically analyzed, with significance defined at p < 0.05 (t-test). No significant difference was noted between the groups for pain and trismus, but Alb-PRF showed a significant reduction in swelling on day seven. The Alb-PRF group showed lower levels of pro-inflammatory cytokines (GM-CSF, IL-1b, IL-6, IFNy, IL-8, IL-15, RANTES, and MIP-1a) after seven days, with only higher expressions of MIP-1b, IL-1b, and MCP-1 found in the L-PRF group. Differences were observed in the release of analytes between L-PRF and Alb-PRF, with Alb-PRF significantly reducing edema after seven days. Alb-PRF reduced edema, while L-PRF increased inflammatory cytokines. When compared to L-PRF, Alb-PRF reduced edema and the release of inflammatory cytokines, suggesting promising effects in socket healing while underscoring the role of growth factors and cytokines in potential applications of blood concentrates.

show abstract

The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis

Cited by 3 publications

References 28 publications

Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

The impact of submucosal PRP injection on wound healing after endoscopic sinus surgery: a randomized clinical trial

Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial

Contact Info

Product

Resources

About