2021
DOI: 10.1371/journal.pone.0249069
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Abstract: Background The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to remain a global challenge. There is emerging evidence of SARS-CoV-2 virus found in the blood of patients from China and some developed countries. However, there is inadequate data reported in Ghana and other parts of Africa, where blood transfusion service heavily relies on voluntary and replacement blood donors. This study aimed to investigate whether plasma of inf… Show more

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Cited by 12 publications
(10 citation statements)
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“…The rRT-PCR analysis revealed that all of the tested donated blood samples were negative for SARS-CoV-2 RNA in the current study. This is consistent with two recent studies [ 27 , 28 ]. Owusu and his colleagues tested plasma from SARS-CoV-2 infected individuals in Ghana, but they found SARS-CoV-2 viral RNA in only 1.03% of the tested plasma samples, concluding that blood transfusion is negligible risk factor for SARS-CoV-2 transmission [ 27 ].…”
Section: Discussionsupporting
confidence: 94%
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“…The rRT-PCR analysis revealed that all of the tested donated blood samples were negative for SARS-CoV-2 RNA in the current study. This is consistent with two recent studies [ 27 , 28 ]. Owusu and his colleagues tested plasma from SARS-CoV-2 infected individuals in Ghana, but they found SARS-CoV-2 viral RNA in only 1.03% of the tested plasma samples, concluding that blood transfusion is negligible risk factor for SARS-CoV-2 transmission [ 27 ].…”
Section: Discussionsupporting
confidence: 94%
“…This is consistent with two recent studies [ 27 , 28 ]. Owusu and his colleagues tested plasma from SARS-CoV-2 infected individuals in Ghana, but they found SARS-CoV-2 viral RNA in only 1.03% of the tested plasma samples, concluding that blood transfusion is negligible risk factor for SARS-CoV-2 transmission [ 27 ]. A systematic review and meta-analysis also revealed that SARS-CoV-2 poses no direct threat to blood safety [ 28 ].…”
Section: Discussionsupporting
confidence: 94%
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“…In contrast, other studies performed on hospitalized patients reported no correlation between the level of SARS-CoV-2 genomes detected in patients and the presentation of severe disease [ 10 , 11 ]. Furthermore, screening of blood donations has identified SARS-CoV-2 RNA-positive donations from patients who were asymptomatic, although the overall prevalence was low [ 12 , 13 , 14 , 15 ]. Although a correlation between viremia versus disease is not well defined, it is clear that SARS-CoV-2 can be found in blood; however, the low prevalence, the inability to isolate infectious virus from SARS-CoV-2 RNA-positive blood samples [ 16 ], and, so far, the lack of COVID-19 symptoms in patients that received blood from SARS-CoV-2 RNA-positive donors [ 12 , 13 ], suggests that the risk of SARS-CoV-2 TTI is relatively low.…”
Section: Introductionmentioning
confidence: 99%
“…In blood, its frequency ranges from 1 to 73% (Chen et al, 2020 ; Hogan et al, 2021 ) in patients with COVID-19, and it seems to be significantly associated with adverse clinical outcomes (Hagman et al, 2021 ). However, the viremia is transient and infrequent, especially in paucisymptomatic or asymptomatic cases of COVID-19 (Andersson et al, 2020 ; Owusu et al, 2021 ). On the contrary, a recent work demonstrated that SARS-CoV-2 RNA could persist for longer periods in the lung (Caniego-Casas et al, 2022 ).…”
Section: Discussionmentioning
confidence: 99%