Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule (派能达胶囊) for Replacing Androgen Partially: A Clinical Multi-Center Study

Jiang, Zhi‐Yong; Yu, Fang-Quan; Gao, Ruilan; Kuang, Yuemin; Zhu, Yan; Chen, Yuehua; Li, Lin-Jie; Ouyang, Guifang; Hu, Jing; Wu, Xiaolong

doi:10.1007/s11655-021-3283-z

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…25 PDS-C was used subsequently for animal studies and clinical trials. 26–28 Our previous research confirmed that PSD-C was effective in reversing hemocytopenia in mice and rats and efficacious and safe in treatment of primary immune thrombocytopenia (ITP), 29 aplastic anemia, 30,31 myelosuppression & hemocytopenia. 32 Our research demonstrated the multiple effects of PDS-C in promoting energy metabolism, modulating immunity, and improving oxidative damage.…”

Section: Introductionmentioning

confidence: 85%

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Mi,

Hu,

Liu

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 85%

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Mi,

Hu,

Liu

et al. 2024

Food Funct.

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“…We also found that among AA patients, patients who used CHMs had lower risks of overall and anemia-related mortalities even after adjusting for age, gender, comorbidities, and usages of immunosuppressive therapy, glucocorticoid usage, hematopoietic growth factor therapy, androgen therapy, chemotherapy, iron chelation therapy, and blood transfusion therapy. CHMs may show the protective effect against bone marrow failure related diseases (Gao and Chong, 2012;Kuang et al, 2016;Sun et al, 2018;Jiang et al, 2021). Ginseng extract and its active component-panaxadiol saponins promote the proliferation and differentiation of hematopoietic progenitor cells and then regulate the immune function (Gao and Chong, 2012;Kuang et al, 2016;Sun et al, 2018;Jiang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…CHMs may show the protective effect against bone marrow failure related diseases (Gao and Chong, 2012;Kuang et al, 2016;Sun et al, 2018;Jiang et al, 2021). Ginseng extract and its active component-panaxadiol saponins promote the proliferation and differentiation of hematopoietic progenitor cells and then regulate the immune function (Gao and Chong, 2012;Kuang et al, 2016;Sun et al, 2018;Jiang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan

et al. 2021

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Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000–2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidence interval (CI): 0.66-0.74, p < 0.001). The risk of anemia-related mortality was lower in CHM-users when compared to non-users (aHR: 0.46, 95% CI: 0.32-0.67, p < 0.001). The association rule analysis revealed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D. Don)→Bai-Hua-She-She-Cao (BHSSC; Oldenlandia diffusa (Willd.) Roxb.), followed by Dang-Gui (DG; Angelica sinensis (Oliv.) Diels)→Huang-Qi (HQi; Astragalus membranaceus (Fisch.) Bunge), and Xian-He-Cao (XHC; Agrimonia pilosa f. borealis (Kitag.) Chu)→Gui-Pi-Tang (GPT). Network analysis showed that BZL, BHSSC, DG, HQi, XHC, GPT, and Dan-Shen (DanS; Salvia miltiorrhiza var. charbonnelii (H.Lév.) C.Y.Wu) were commonly used CHMs for AA patients. Therefore, further studies for these commonly prescribed herbs are needed in functional investigations in hematopoiesis-stimulating effect and large-scale randomized controlled trials (RCT) in bone marrow failure related diseases.

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Hematopoiesis reconstitution and anti-tumor effectiveness of Pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation

Yuan¹,

Lü²,

Cao³

et al. 2022

WJCC

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Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule (派能达胶囊) for Replacing Androgen Partially: A Clinical Multi-Center Study

Cited by 3 publications

References 3 publications

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan

Hematopoiesis reconstitution and anti-tumor effectiveness of Pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation

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