Effect of Platelet-Rich Plasma on Bone Healing in Immediate Implants Analyzed by Cone Beam Computerized Tomography: A Randomized Controlled Trial

Abstract

The possibility of platelet-rich plasma (PRP) on the improvement of bone and adjacent tissue recovery has previously been validated. However, there is insufficient data supporting the use of platelet-rich plasma to improve the healing of bone and adjacent tissues around an implant in the oral cavity. The purpose of this randomized controlled trial was to observe the effect of platelet-rich plasma (PRP) concentrate on marginal bone loss and bone density around immediate implant placement using Cone Beam Computerized Tomography (CBCT). This clinical study was conducted over a period of six months on 12 subjects, who were equally categorized into two groups. Group I was the control, whereas the subjects in Group II received PRP therapy at the surgical site. All subjects were given a standard treatment with a single implant system (DIO UFII hybrid sandblasted acid-etched implants). Inserted implants were analyzed through CBCT, and records were registered at baseline, at the 12th week before functional loading and the 26th week after functional loading. The bone loss was calculated at the proximal (mesial and distal) side of the implant and bone density at baseline, 12th week, and 26th week after implant placement. SPSS version 23.0 was used for statistical analysis of data. The changes in bone levels were measured and compared between the two groups using the Mann–Whitney U test, with no significant difference. Bone density was analyzed by an independent sample t -test, p value ≤ 0.05 was considered statistically significant. Again, no significant difference in bone density was observed between both groups at all three instances. Therefore, it can be concluded that local injection of PRP after immediate implant placement did not show any decrease in marginal bone loss or improvement in bone density. This trial is registered with NCT04650763.

Effects of platelet concentrates on implant stability and marginal bone loss: a systematic review and meta-analysis

“…By reading the complete text, 18 articles were screened out for some reasons. Finally, 14 articles were included [ 1 , 6 , 16 , 17 , 21 – 25 , 28 , 40 – 43 ], and 13 of them were meta-analyzed. The process of literature search and screening is shown in Fig.…”

“…The included articles were published from 2005 to 2021, and 9 were published in the past 5 years [ 1 , 6 , 16 , 22 – 24 , 28 , 42 , 43 ]. 9 studies were RCTs [ 1 , 17 , 21 , 25 , 28 , 42 , 43 ] [ 22 , 23 ] and 5 were CCTs [ 6 , 16 , 24 , 40 , 41 ].…”

“…The included articles were published from 2005 to 2021, and 9 were published in the past 5 years [ 1 , 6 , 16 , 22 – 24 , 28 , 42 , 43 ]. 9 studies were RCTs [ 1 , 17 , 21 , 25 , 28 , 42 , 43 ] [ 22 , 23 ] and 5 were CCTs [ 6 , 16 , 24 , 40 , 41 ]. For the platelet concentrates used in the studies, 8 studies used PRF [ 6 , 21 – 25 , 42 , 43 ], 2 used CGF [ 1 , 16 ], and 4 used PRP [ 17 , 28 , 40 , 41 ].…”

“…9 studies were RCTs [ 1 , 17 , 21 , 25 , 28 , 42 , 43 ] [ 22 , 23 ] and 5 were CCTs [ 6 , 16 , 24 , 40 , 41 ]. For the platelet concentrates used in the studies, 8 studies used PRF [ 6 , 21 – 25 , 42 , 43 ], 2 used CGF [ 1 , 16 ], and 4 used PRP [ 17 , 28 , 40 , 41 ]. For the method of application, researchers dipped implants in the platelet concentrate liquid before insertion in 7 studies [ 1 , 17 , 21 , 24 , 40 , 41 , 43 ]and only placed them in the implant sites in 7 studies [ 6 , 16 , 22 , 23 , 25 , 28 , 42 ].…”

“…González-Serrano et al only analyzed one outcome (MBL) and Miron et al did not conduct a meta-analysis [ 27 ]. In addition, some randomized controlled trials published in the past five years have not been included in these studies [ 1 , 16 , 28 ]. Therefore, the purpose of this study is to systematically review the randomized controlled trials and controlled clinical trials of platelet concentrates in oral implantology and conduct a meta-analysis of the effects of platelet concentrates on implant stability and marginal bone loss.…”