The application of platelet-rich plasma in the treatment of knee osteoarthritis: A literature review

Li, Wei; Pan, Jinhe; Lu, Zhihui; Zhu, Huangrong; Guo, Jinshan; Xie, Denghui

doi:10.1016/j.jos.2021.01.006

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…This also confirms the role of PRP in treating diseases other than KOA. Combined with the randomized controlled trials of Li W et al [34], adverse reactions caused by adverse PRP were nonspecific and mostly related to the injection operation itself. Therefore, these adverse reactions usually resolve spontaneously within a few days, with high safety.…”

Section: Safety Evaluation Of Prpmentioning

confidence: 90%

Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis

2022

FMSR

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Knee osteoarthritis is a common and frequently occurring disease in clinic, and degeneration of articular cartilage is one of the main causes of this disease. Delaying cartilage degeneration and promoting cartilage repair are important ways to relieve pain and improve function. PRP is an autologous product derived from highly centrifugal blood, which contains a high concentration of effective factors, which can maintain tissue homeostasis and regulate the body's inflammation and coagulation. The product can regulate bone and blood vessel remodeling, inhibit chondrocyte apoptosis, inhibit inflammatory reaction and promote collagen synthesis by injection into the joint. PRP has unique advantages in the treatment of knee osteoarthritis, and has become one of the feasible methods for clinical treatment of KOA. Based on this, through this review, the author will elaborate the preparation of PRP, the mechanism of ACTION of KOA, the safety evaluation, the advantages of PRP and other treatment methods, and the combination of PRP and TRADITIONAL Chinese medicine in the treatment of knee osteoarthritis, aiming to provide new ideas, new methods and new methods for clinical diagnosis and treatment.

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Section: Safety Evaluation Of Prpmentioning

confidence: 90%

Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis

2022

FMSR

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“…Regarding complications, PRP did not increase the risk of adverse events compared with HA. Compared with many other treatment methods, the intra-articular injection of PRP was proven to be a safe and effective means of improving the quality of life of patients with knee OA [43].…”

Section: Systematic Reviews and Meta-analysesmentioning

confidence: 99%

“…In patients with knee OA, LR-PRP demonstrated effectiveness in meaningful end points for functional and patient-reported outcomes at early time points [51]. Table 2 summarizes the efficacy of intra-articular PRP injections in knee OA [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51].…”

Section: Case Seriesmentioning

confidence: 99%

Intra-Articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Review of Their Current Molecular Mechanisms of Action and Their Degree of Efficacy

Rodríguez-Merchán

2022

IJMS

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Knee osteoarthritis (OA) is estimated to affect more than 10% of the population, with a lifetime risk of 45%. Contemporary guidelines advise control of body weight, therapeutic physical exercise, drug treatment (oral non-steroidal anti-inflammatory drugs, paracetamol, opioids), and mechanical aids (walking aids, braces, orthoses). Nevertheless, these treatments typically have only short-term benefits. Intra-articular corticosteroids are typically advised, but only for short-term pain alleviation, given that their benefits last only a few weeks. The efficacy of hyaluronic acid is controversial. When the aforesaid options fail, total knee arthroplasty is generally recommended as an efficacious treatment. However, it is costly and can involve medical and postoperative complications. Therefore, determining alternate safe and effective treatments for knee OA is paramount. Platelet-rich plasma (PRP) has lately been investigated for the treatment of knee OA. This article reviews recent knowledge concerning PRP’s molecular mechanisms of action. The effectiveness of intra-articular PRP injections in the knee joint remains controversial, although most recent publications show pain alleviation in the short term. Orthopedic surgeons treating people with knee OA are becoming increasingly interested in PRP, despite indecisive clinical data and basic science information. Further studies comparing PRP with placebo are required.

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“…Public interest in and use of platelet-rich plasma (PRP) injections has greatly increased over the past decade [5]. Although PRP injections have been FDA-approved and are deemed safe, their clinical efficacy for the treatment of osteoarthritis (OA) is unclear [4,7,15,19,24,26,29]. Recent guidelines, including those from the American Academy of Orthopaedic Surgeons, indicate that only limited evidence suggests that PRP injections reduce pain or improve function in patients with symptomatic knee OA [1,14].…”

Section: Introductionmentioning

confidence: 99%

There Is Wide Variation in Platelet-rich Plasma Injection Pricing: A United States Nationwide Study of Top Orthopaedic Hospitals

Tiao,

Wang,

Herrera

et al. 2023

Clin Orthop Relat Res

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Background Demand for platelet-rich plasma (PRP) injections for osteoarthritis has dramatically increased in recent years despite conflicting evidence regarding its efficacy and highly variable pricing in the top orthopaedic centers in the United States, because PRP is typically not covered by insurance. A previous study investigating the mean price of PRP injections obtained information only from centers advertising online the availability of PRP injections. Thus, there is a need for further clarification of the overall availability and variability in cost of PRP injections in the orthopaedic community as well as an analysis of relevant regional demographic and hospital characteristics that could be associated with PRP pricing. Questions/purposes Our study purposes were to (1) report the availability and price variation of knee PRP injections at top-ranked United States orthopaedic centers, (2) characterize the availability of pricing information for a PRP injection over the telephone, (3) determine whether hospital characteristics (Orthopaedic Score [U.S. News & World Report measure of hospital orthopaedic department performance], size, teaching status, and rural-urban status) were associated with PRP injection availability and pricing, and (4) characterize the price variation, if it exists, of PRP injections in three metropolitan areas and individual institutions. Methods In this prospective study, a scripted telephone call to publicly listed clinic telephone numbers was used to determine the availability and price estimate (amount to be paid by the patient) of a PRP injection for knee osteoarthritis from the top 25 hospitals from each United States Census region selected from the U.S. News & World Report ranking of best hospitals for orthopaedics. Univariable analyses examined factors associated with PRP injection availability and willingness to disclose pricing, differences across regions, and the association between hospital characteristics (Orthopaedic Score, size, teaching status, and rural-urban status) and pricing. The Orthopaedic Score is a score assigned to each hospital by U.S. News & World Report as a measure of hospital performance based partly on patient outcomes, with higher scores indicating better outcomes. Results Overall, 87% (87 of 100) of respondents stated they offered PRP injections. Pricing ranged from USD 350 to USD 2815 (median USD 800) per injection, with the highest prices in the Northeast. The largest price range was in the Midwest, where more than two-thirds of PRP injections given at hospitals that disclosed pricing cost USD 500 to USD 1000. Of the hospitals that offered PRP injections, 68% (59 of 87) were willing to disclose price information over the telephone. PRP injection pricing was inversely correlated with hospital Orthopaedic Score (-3% price change [95% CI -5% to -1%]; p = 0.01) and not associated with any of the other hospital characteristics that were studied, such as patient population median income and total hospital expenses. An intracity analysis revealed wide variations in PRP pricing in all metropolitan areas that were analyzed, ranging from a minimum of USD 300 within 10 miles of metropolitan area B to a maximum of USD 1269 within 20 miles of metropolitan area C. Conclusion We found that although PRP injections are widely available, pricing continues to be a substantial financial burden on patients, with large price variability among institutions. We also found that if patients are willing to shop around in a metropolitan area, there is potential to save a meaningful amount of money. Clinical Relevance As public interest in biologics in orthopaedic surgery increases, knowledge of its pricing should be clarified to consumers. The debated efficacy of PRP injections, combined with our findings that it is an expensive out-of-pocket procedure, suggests that PRP has limited cost-effectiveness, with variable, discrete pricing. As such, the price of PRP injections should be clearly disclosed to patients so they can make informed healthcare decisions.

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The application of platelet-rich plasma in the treatment of knee osteoarthritis: A literature review

Cited by 5 publications

References 24 publications

Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis

Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis

Intra-Articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Review of Their Current Molecular Mechanisms of Action and Their Degree of Efficacy

There Is Wide Variation in Platelet-rich Plasma Injection Pricing: A United States Nationwide Study of Top Orthopaedic Hospitals

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