337 Monocyte chemotactic protein-1 (MCP-1) enhances the severity of HSV-induced myelitis through the stimulation of Th2 responses

Nakajima, Hideo; Kobayashi, Masahide; Pollard, Richard B.; Suzuki, Fujio

doi:10.1016/s0091-6749(00)90766-8

Cited by 20 publications

(23 citation statements)

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“…Out of the six chemokines investigated, only CCL2 levels were associated with sensitivity to infection since CXCL10−/ − mice possessed significantly more virus and expressed elevated levels of CCL2 in the cornea in comparison to the less sensitive WT or CXCL9−/− mice. CCL2 has been linked to increased pathogenesis and mortality in mice infected with HSV-1 [38] perhaps thru a T H 1 to T H 2 switch [39]. However, we have not been able to detect IL-4 and rarely detect IL-10 at the protein level in the corneas of these mice.…”

Section: Cd4 + T Cell Infiltration Into the Cornea Is Reduced In Cxclmentioning

confidence: 56%

CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection

Wuest

Farber

Luster

et al. 2006

Cellular Immunology

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The role of CXCL9 and CXCL10 in the ocular immune response to herpes simplex virus type 1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10. CXCL10 but not CXCL9 deficient mice showed an increase in sensitivity to ocular virus infection as measured by an elevation in virus titer recovered in the tear film and corneal tissue. The increase in virus was associated with an increase in the expression of the chemokine CCL2 but no significant change in the infiltration of CD4 + T cells or NK cells into the corneal stroma. In contrast, a significant reduction in CD4 + T cell infiltration into the cornea was found in CXCL9 deficient mice following HSV-1 infection consistent with the absence of CXCL9 expression and reduction in expression of other chemokines including CCL3, CCL5, CXCL1, and CXCL10. Collectively, the results suggest a nonredundant role for CXCL9 and CXCL10 in response to ocular HSV-1 infection in terms of controlling virus replication and recruitment of CD4 + T cells into the cornea.

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Section: Cd4 + T Cell Infiltration Into the Cornea Is Reduced In Cxclmentioning

confidence: 56%

CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection

Wuest

Farber

Luster

et al. 2006

Cellular Immunology

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show abstract

“…The present study was undertaken to measure concentrations of the chemokine RANTES, IL-8, and MCP-1 in sera from the animals immunized with the Y. pestis 201 or the EV. Elevated levels of two chemokines IL-8, a mediator of Th1 type cellular immune responses, 54 and MCP-1 predominantly chemotactic for Th2 cells, 55 were observed in sera from the animals immunized with the Y. pestis 201 or the EV. These observations revealed that the protection provided by these 2 live attenuated vaccines was at least attributed to both the chemoattraction of IL-8 and MCP-1, and the modulation of Th1/Th2 balance.…”

Section: 84142mentioning

confidence: 99%

Yersinia pestisbiovarMicrotusstrain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques

Zhang

Wang

Guang

et al. 2013

Human Vaccines & Immunotherapeutics

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“…In humans and other vertebrate animals, activated T cells that infiltrate the CNS during encephalitic DNA or RNA viral infections up-regulate expression of the chemokine receptors CCR1, CCR2, CCR5, and CXCR3 and their chemokine ligands CCL2 (CCR2), CCL3 (CCR1, CCR5), CCL4 (CCR5), CCL5 (CCR1, CCR5), and CXCL9 -CXCL11 (CXCR3) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Although targeted deletion of CXCR3 or CXCL10 is associated with a reduction in infiltrating mononuclear cells and enhanced mortality from infection of the CNS with mouse hepatitis virus (MHV) 3 (25,26), few studies have examined regional differences in the expression of chemokine ligands during viral encephalitis.…”

Section: T He Infiltration Of Virus-specific Cd8 T Cells Is Essentialmentioning

confidence: 99%

CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis

Zhang

Chan

Liu

et al. 2008

The Journal of Immunology

162

147

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Regional differences in inflammation during viral infections of the CNS suggest viruses differentially induce patterns of chemoattractant expression, depending on their cellular targets. Previous studies have shown that expression of the chemokine CXCL10 by West Nile virus (WNV)-infected neurons is essential for the recruitment of CD8 T cells for the purpose of viral clearance within the CNS. In the current study we used mice deficient for the CXCL10 receptor, CXCR3, to evaluate its role in leukocyte-mediated viral clearance of WNV infection within various CNS compartments. WNV-infected CXCR3-deficient mice exhibited significantly enhanced mortality compared with wild-type controls. Immunologic and virologic analyses revealed that CXCR3 was dispensable for control of viral infection in the periphery and in most CNS compartments but, surprisingly, was required for CD8 T cell-mediated antiviral responses specifically within the cerebellum. WNV-specific, CXCR3-expressing T cells preferentially migrated into the cerebellum, and WNV-infected cerebellar granule cell neurons expressed higher levels of CXCL10 compared with similarly infected cortical neurons. These results indicate that WNV differentially induces CXCL10 within neuronal populations and suggest a novel model for nonredundancy in chemokine-mediated inflammation among CNS compartments.

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337 Monocyte chemotactic protein-1 (MCP-1) enhances the severity of HSV-induced myelitis through the stimulation of Th2 responses

Cited by 20 publications

References 0 publications

CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection

CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection

Yersinia pestisbiovarMicrotusstrain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques

CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis

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