2021
DOI: 10.1353/hpu.2021.0011
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Abstract: Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, thre… Show more

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Cited by 3 publications
(2 citation statements)
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“…Because hydroxyurea is given at home, it is essential that the patient and family understand the need for strict adherence and also that the care team is aware of social factors that may complicate the patient's ability to obtain and take their medication. [66][67][68] Continued TCD monitoring is necessary. Hydroxyurea appears to be safe for long-term use, but study of its secondary effects, such as infertility, is ongoing.…”
Section: Transfusion Complications and Iron Overloadmentioning
confidence: 99%
“…Because hydroxyurea is given at home, it is essential that the patient and family understand the need for strict adherence and also that the care team is aware of social factors that may complicate the patient's ability to obtain and take their medication. [66][67][68] Continued TCD monitoring is necessary. Hydroxyurea appears to be safe for long-term use, but study of its secondary effects, such as infertility, is ongoing.…”
Section: Transfusion Complications and Iron Overloadmentioning
confidence: 99%
“…Pediatric and adult studies have identified multiple barriers that contribute low hydroxyurea utilization among patients with SCD, including patient forgetfulness, difficulty obtaining refills, lack of access to quality healthcare and/or specialist care, and concerns about effectiveness and side effects on the part of patients and providers alike[51]. While high-quality studies evaluating interventions designed to increase utilization of hydroxyurea have thus far been lacking[52,53], several relevant trials are currently underway[54,55].…”
mentioning
confidence: 99%