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Cited by 239 publications
(281 citation statements)
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References 28 publications
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“…The results of the CONFIRM trial (RCT comparing terlipressin vs. placebo) comprising a considerably higher number of patients, as compared to previous studies, were recently published and clearly established the efficacy of terlipressin on reversal of HRS type 1 (32% vs. 17% in placebo group). Of note, the old ICA criteria 20 (sCr cut-off of 2.25 instead of of 2.5 mg/dL) were applied in that study, probably delaying treatment initiation 106 . However, that study found no difference in overall and transplant-free survival (about 50% in both groups) after 90 days, underlining the paramount importance of liver transplantation to improve outcomes beyond kidney function.…”
Section: Managementmentioning
confidence: 89%
“…The results of the CONFIRM trial (RCT comparing terlipressin vs. placebo) comprising a considerably higher number of patients, as compared to previous studies, were recently published and clearly established the efficacy of terlipressin on reversal of HRS type 1 (32% vs. 17% in placebo group). Of note, the old ICA criteria 20 (sCr cut-off of 2.25 instead of of 2.5 mg/dL) were applied in that study, probably delaying treatment initiation 106 . However, that study found no difference in overall and transplant-free survival (about 50% in both groups) after 90 days, underlining the paramount importance of liver transplantation to improve outcomes beyond kidney function.…”
Section: Managementmentioning
confidence: 89%
“…Several placebo-controlled studies of terlipressin have shown a significant effect on recovery of HRS [ 38 , 39 ]. The effectiveness is definite; however, terlipressin induced several adverse events, including severe respiratory failure.…”
Section: Management Of Ascitesmentioning
confidence: 99%
“…The effectiveness is definite; however, terlipressin induced several adverse events, including severe respiratory failure. In the newest prospective study, respiratory failure was predominant in the terlipressin group; the incidence was nearly three times that in the placebo group [ 39 ]. This effect must be in part associated with the activation of the V2 receptor by terlipressin, followed by increased water reabsorption.…”
Section: Management Of Ascitesmentioning
confidence: 99%
“…Terlipressin was proven to be more effective than placebo in treating HRS type 1 although terlipressin use was associated with more adverse events such abdominal pain, nausea, diarrhea and respiratory failure [37].…”
Section: Vasopressin Analogues (Terlipressin)mentioning
confidence: 99%