2021
DOI: 10.1161/strokeaha.120.032266
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Abstract: Background and Purpose: Patients with intracerebral hemorrhage (ICH) have oxidative stress. Oxidative stress contributes to the development and progression of perihematomal edema (PHE) in brain hemorrhage patients. We hypothesized that reactive oxygen species (ROS) scavengers might have a neuroprotective role in the acute period of patients with ICH. Methods: This prospective, multicenter, single-blind, randomized study was conducted between June 2017 a… Show more

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Cited by 14 publications
(5 citation statements)
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“…Here, we report the pharmacology of different organic, inorganic, and synthetic selenocompounds against ferroptosis in vitro, and demonstrate that selenocystamine and methylselenocysteine are protective in the MCAO model, where ferroptosis is implicated. The translational potential of selenium for stroke is evidenced by a recent study that demonstrated that combined use of selenite with another anti-ferroptotic compound, N-acetylcysteine, improved multiple outcomes in a clinical trial of 123 patients with intracerebral haemorrhage [26]. This clinical trial supports prior findings in animal models that use selenium for hemorrhagic and ischemic stroke.…”
Section: Discussionsupporting
confidence: 69%
“…Here, we report the pharmacology of different organic, inorganic, and synthetic selenocompounds against ferroptosis in vitro, and demonstrate that selenocystamine and methylselenocysteine are protective in the MCAO model, where ferroptosis is implicated. The translational potential of selenium for stroke is evidenced by a recent study that demonstrated that combined use of selenite with another anti-ferroptotic compound, N-acetylcysteine, improved multiple outcomes in a clinical trial of 123 patients with intracerebral haemorrhage [26]. This clinical trial supports prior findings in animal models that use selenium for hemorrhagic and ischemic stroke.…”
Section: Discussionsupporting
confidence: 69%
“…A recent clinical trial has demonstrated that the combination of selenium with NAC, one of the most widely used antioxidant drugs in preclinical and clinical studies, effectively reduced the perihematomal edema in patients with intracerebral hemorrhage. 48 However, no studies have investigated the effects of this combinational therapy following ischemic stroke. We show that combining selenium with NAC, results in a further significant decrease in infarct volume 1 d after ischemia compared to selenium alone, which also translates to an improvement in functional recovery.…”
Section: Discussionmentioning
confidence: 99%
“…NCT03589495). In patients ICH with oxidative stress, was shown to NAC substantially reduce perihematomal edema volume and shorten intensive care unit stay ( 216 ). Furthermore, NAC has been shown to significantly improve remission maintenance in ulcerative colitis patients receiving 800 mg NAC for 16 weeks unlike the placebo ( 217 ).…”
Section: Clinical Perspectivesmentioning
confidence: 99%