Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet‐rich fibrin: A randomized controlled clinical trial

Abstract

Background: To investigate the regenerative effect of adjunctive use of guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and plateletrich fibrin (PRF) in intrabony defects. Methods: Fourteen participants were enrolled, and for each patient their left and right two sides were randomized to the test group or control group. Only the worst intrabony defect on each side was analyzed. The test group received GTR, BPBM, and PRF, whereas the control group received only GTR and BPBM. The PRF used in the trial was fluid PRF, which combined with the BPBM to form a BPBM-PRF complex. The patients were followed up by clinical and radiographic evaluation for 24 months after surgery.Results: Probing depth (PD) in the test group was significantly less than that in the control group at 12 and 24 months after surgery, and the mean difference was ≈ 0.5 to 0.7 mm. Clinical attachment level (CAL) gain in the test group was ≈ 0.9 mm higher than that in the control group at 6 months after surgery, and the difference reached 1.0 to 1.1 mm 12 and 24 months after surgery. None of the other clinical or radiographic parameters differed significantly between the two groups at any time-point after the surgery. Conclusion:Compared with GTR and BPBM, the combination of GTR and BPBM-PRF complex is more effective clinically, and results in better clinical outcomes.

The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis

“…Several questions arise on the combined PRF/OG that only the histologic evaluation can answer, such as the nature of the tissues in the healed defect, the amount of newly formed bone, the amount of residual bone substitute, the contact between new bone and bone substitute and the possible acceleration of the bone formation process. Future studies should address the combined use of L-PRF, OG and GTR, as compared without L-PRF, since there is only one such study for PRF [ 87 ]. Such a comparison in non-contained defects would be challenging.…”

Platelet-rich fibrin/anorganic bovine bone mineral complex as grafting materials in endodontic microsurgery with a large lesion size: study protocol for a randomised controlled trial

“… 24 The complex together with a collagen membrane has been demonstrated to result in enhanced gains in attachment level compared with ABBM alone with a collagen membrane, indicating improved periodontal regeneration. 24 …”

“…Moreover, the presence of leucocytes is helpful for their anti-infection and immunomodulatory effects 15–17. Previously, PRF has been extensively used in dentistry, including the healing of extraction sockets,18 ridge preservation,19 maxillary sinus augmentation and the regeneration of periodontal lesions 20–24. It promotes the healing of soft tissue, and reduces postoperative pain, swelling and the incidence of alveolar osteitis after the extraction of impacted mandibular third molars 18.…”

“…The combination of PRF and deproteinised bovine bone mineral has been shown to increase bone formation in maxillary sinus augmentation compared with deproteinised bovine bone mineral alone 20. Plenty of studies have indicated that combinations of PRF and bone grafting materials enhance periodontal regeneration in periodontal intrabony defects 21–24. In a word, PRF has the potential for osseous regeneration and healing of soft tissue, especially when combined with various bone grafting materials 25.…”

Effects of DDR1 on migration and adhesion of periodontal ligament cells and the underlying mechanism

“…hPDLCs have been shown to have the strongest regenerative properties when compared to other cells derived from the periodontium. 52,53 It is essential to ensure hPDLCs preferentially occupy the root surface to facilitate periodontal regeneration. Cells must interact with their environment through adhesion receptors to migrate.…”