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Cited by 15 publications
(11 citation statements)
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References 30 publications
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“…Osmotic diuresis following mannitol can exacerbate hypotension and potentially worsen secondary brain injury. A retrospective analysis of an international multicentre randomised controlled trial (568 patients) found a statistically significant incidence of acute kidney injury with mannitol (hazard ratio, HR 2.3, 95% confidence interval, CI:1.2 to 4.3, P=0.01), but not with HTS (HR 1.6, 95% CI: 0.9 to 2.8, P=0.08) in moderate to severe TBI 13…”
Section: What Is the Evidence Of Uncertainty?mentioning
confidence: 99%
“…Osmotic diuresis following mannitol can exacerbate hypotension and potentially worsen secondary brain injury. A retrospective analysis of an international multicentre randomised controlled trial (568 patients) found a statistically significant incidence of acute kidney injury with mannitol (hazard ratio, HR 2.3, 95% confidence interval, CI:1.2 to 4.3, P=0.01), but not with HTS (HR 1.6, 95% CI: 0.9 to 2.8, P=0.08) in moderate to severe TBI 13…”
Section: What Is the Evidence Of Uncertainty?mentioning
confidence: 99%
“…This pathology is commonly known as “osmotic nephrosis” or “sucrose nephrosis” ( Figure 3 ). Several studies showed that intravenous administration of immune globulin, mannitol, contrast media, hydroxyethyl starch solutions, or glucose can induce AKI injury via osmotic cell destruction [ 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. It was well-documented that osmotically active agents entered the tubular cells by means of pinocytosis, leading to cellular edema with increased lysosomes and endocytotic vacuoles.…”
Section: Plasma Hyperosmolality and The Kidneymentioning
confidence: 99%
“…Several studies documented AKI following mannitol administration [ 62 , 69 , 70 , 71 ]. Mannitol-induced osmotic nephrosis has been well-documented, as it exerts nephrotoxic activity [ 61 , 62 , 63 , 65 , 72 ]. There is a dose–response relationship between the use of mannitol and the incidence and severity of AKI, with a cut-off of the daily dose at 1.34 g/kg body weight [ 73 ].…”
Section: Plasma Hyperosmolality and The Kidneymentioning
confidence: 99%
“…3 The First Clinical Medical College of Lanzhou University, Gansu Lanzhou 730000, China. 4 Department of Rehabilitation, The First Hospital of Lanzhou University, Gansu Lanzhou 730000, China. 5 School of Public Health, Lanzhou University, Gansu Lanzhou 730000, China.…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%
“…Data showed that about half of the global population experienced an episode of TBI in their lifetime, causing huge economic losses to the world every year [3]. TBI has been a pressing global medical and public health problem and a leading cause of mortality and long-term disability [4].…”
Section: Introductionmentioning
confidence: 99%