2021
DOI: 10.3390/medicina57020144
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Abstract: Background and Objectives: The aim of the present systematic review and meta-analysis was to investigate the efficacy of leukocyte–platelet-rich fibrin (L-PRF) in addition to coronally advanced flap (CAF) for the treatment of both single and multiple gingival recessions (GRs) compared to the CAF alone and to the adjunct of connective tissue graft (CTG). Root coverage outcomes using platelet concentrates have gained increased interest. In particular, it has been suggested that adding L-PRF to CAF may provide fu… Show more

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Cited by 15 publications
(7 citation statements)
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“…The products from the blood centrifugations are widely used, either alone or in combination with the heterologous grafting materials due to the contents of the growth factors [17].…”
Section: Introductionmentioning
confidence: 99%
“…The products from the blood centrifugations are widely used, either alone or in combination with the heterologous grafting materials due to the contents of the growth factors [17].…”
Section: Introductionmentioning
confidence: 99%
“…In the scientific literature, there are 16 systematic reviews with meta-analysis on this topic [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. The two main systematic reviews with meta-analysis are Atieh et al [ 37 ] and Huang et al [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…The clinical applications of these preparations are in various areas such as guided periodontal and bone regeneration, sinus floor elevation, and support for the regeneration of the pulp-dentine complex [ 46 , 47 , 48 ]. However, there is no shortage of studies highlighting the limited effects of, for example, the efficacy of PRP in bone formation during sinus floor elevation procedures, as noted in the systematic review by Pocaterra et al [ 49 ].…”
Section: Role Of Platelets Derivates In Regenerative Dental Proceduresmentioning
confidence: 99%
“…L-PRF has also been used in the treatment of single and multiple gingival recessions in conjunction with the coronal repositioning flap (CAF) technique; the efficacy of this, compared with CAF alone and with the addition of connective graft, was the subject of the study by Mancini et al [ 47 ], who concluded their review by reporting that there were statistically significant results in mean root coverage, reduction in recession, gain in keratinized tissue width, gain in gingival thickness, patient perception of pain and discomfort with the use of L-PRF compared to CAF alone, but not in relation to the addition of connective graft in single and multiple CAF. The latter, however, showed statistically significant results only in relation to the patient’s perception of pain and discomfort.…”
Section: Role Of Platelets Derivates In Regenerative Dental Proceduresmentioning
confidence: 99%