2021
DOI: 10.1186/s12871-021-01234-8
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Abstract: Background The blood saving efficacy of TXA in cardiac surgery has been proved in several studies, but TXA dosing regimens were varied in those studies. Therefore, we performed this study to investigate if there is a dose dependent in-vivo effect of TXA on fibrinolysis parameters by measurement of fibrinolysis markers in adults undergoing cardiac surgery with CPB. Methods A double-blind, randomized, controlled prospective trial was conducted from F… Show more

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Cited by 2 publications
(1 citation statement)
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“…9 Although clinical studies have tried different doses (for bolus and infusion) during cardiac surgery to determine which ones lead to plasma concentrations associated with fibrinolysis inhibition, results remain unclear. In several studies indeed, different doses did not lead to different results on biological measurements, 4,10 questioning the link between dose administered, plasma concentration and biological efficacy.…”
Section: Commentmentioning
confidence: 99%
“…9 Although clinical studies have tried different doses (for bolus and infusion) during cardiac surgery to determine which ones lead to plasma concentrations associated with fibrinolysis inhibition, results remain unclear. In several studies indeed, different doses did not lead to different results on biological measurements, 4,10 questioning the link between dose administered, plasma concentration and biological efficacy.…”
Section: Commentmentioning
confidence: 99%