Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)

Laíns, Inês; Wang, Jay C.; Cui, Ying; Katz, Raviv; Vingopoulos, Filippos; Staurenghi, Giovanni; Vavvas, Demetrios G.; Miller, Joan W.; Miller, John B.

doi:10.1016/j.preteyeres.2021.100951

Cited by 140 publications

(64 citation statements)

References 428 publications

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“…Swept-source OCTA (SS-OCTA) that uses a faster scanning speed (100,000 A-scan/s) and a longer wavelength (1050 nm) than spectral-domain OCTA has been recently clinically introduced with the advantage of better penetration of the retinal pigment epithelium by the laser beams and, consequently, better visualization of the choriocapillaris. 14 Nevertheless, few studies have investigated the quantitative anatomy of the choriocapillaris in normal and diseased conditions. These investigations suggested that age-related macular degeneration and Stargardt´s disease were associated with decreased macular choriocapillaris perfusion.…”

Section: Introductionmentioning

confidence: 99%

Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

Cheng

Song

Lin

et al. 2022

American Journal of Ophthalmology

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Section: Introductionmentioning

confidence: 99%

Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

Cheng

Song

Lin

et al. 2022

American Journal of Ophthalmology

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“…Optical coherence tomography angiography (OCTA) permits non-invasive, detailed, and depth-resolved imaging of the chorioretinal microvasculature in disease states such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and uveitis (9)(10)(11)(12)(13)(14)(15). In addition, several OCTA studies have documented changes in the chorioretinal microvasculature associated with VKH disease (16)(17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Microvasculature Features of Vogt-Koyanagi-Harada Disease Revealed by Widefield Swept-Source Optical Coherence Tomography Angiography

Zhang

Xiao

et al. 2021

Front. Med.

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Background: Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune disorder which could induce bilateral panuveitis involving the posterior pole and peripheral fundus. Optical coherence tomography angiography (OCTA) provides several advantages over traditional fluorescence angiography for revealing pathological abnormalities of the retinal vasculature. Until recently, however, the OCTA field of view (FOV) was limited to 6 × 6 mm2 scans.Purpose: This study examined retinal vasculature and choriocapillaris abnormalities across multiple regions of the retina (15 × 9 mm2 wide field, macular, peripapillary regions) among acute and convalescent VKH patients using a novel widefield swept-source OCTA (WSS-OCTA) device and assessed correlations between imaging features and best-corrected visual acuity (BCVA).Methods: Twenty eyes of 13 VHK disease patients in the acute phase, 30 eyes of 17 patients in the convalescent phase, and 30 eyes of 15 healthy controls (HCs) were included in this study. Vascular length density (VLD) in superficial and deep vascular plexuses (SVP, DVP), vascular perfusion density (VPD) in SVP, DVP, and choriocapillaris (CC), and flow voids (FV) in CC were measured across multiple retinal regions via WSS-OCTA (PLEX Elite 9000, Carl Zeiss Meditec Inc., USA) using the 15 × 9 mm2 scan pattern centered on the fovea and quantified by ImageJ.Results: Compared to HCs, acute phase VKH patients exhibited significantly reduced SVP-VLD, SVP-VPD, and CC-VPD across multiple retinal regions (all p < 0.01). Notably, the FV area was more extensive in VKH patients, especially those in the acute phase (p < 0.01). These changes were reversed in the convalescent phase. Stepwise multiple linear regression analysis demonstrated that macular DVP-VLD and macular CC-VPD were the best predictive factors for BCVA in the acute and convalescent VKH groups.Conclusion: The wider field of SS-OCAT provides more comprehensive and detailed images of the microvasculature abnormalities characterizing VKH disease. The quantifiable and layer-specific information from OCTA allows for the identification of sensitive and specific imaging markers for prognosis and treatment guidance, highlighting WSS-OCTA as a promising modality for the clinical management of VKH disease.

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“…Our findings support our hypothesis that SS-OCTA offers improved resolution of deeper retinal and choroidal vessels as compared to SD-OCTA and thus might be better suited to capture alterations in choroidal perfusion. 19 Comparative studies have demonstrated improved visualization of the choroid attributed to enhanced choroidal penetration using SS-OCTA compared to SD-OCTA in eyes with clinically significant cataract and AMD. 20,21 In addition, SS-OCTA has demonstrated greater accuracy in detecting CC flow impairment under drusen and visualizing the macula in gas-filled eyes post-vitrectomy for macular holes and retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

Detection of choroidal hypoperfusion in giant cell arteritis using swept-source optical coherence tomographic angiography

Yuan

et al. 2021

Preprint

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Objective: To determine whether swept-source optical coherence tomographic angiography (SS-OCTA) can demonstrate choroidal perfusion abnormalities seen on fluorescein angiography (FA) in giant cell arteritis (GCA). Design: Observational case series. Participants: Six eyes of 3 patients with bilateral ischemic optic neuropathy secondary to GCA, and one control patient without ocular involvement from biopsy-confirmed GCA. Methods: En face SS-OCTA (DRI OCT Triton, Topcon, Tokyo, Japan) and FA centered on the macula were obtained at presentation. SS-OCTA was segmented into superficial and deep retinal capillary plexuses and the choriocapillaris laminae. SS-OCTA images were independently analyzed for perfusion abnormalities and compared with corresponding FA images. Main Outcome Measures: Correspondence of choroidal angiographic abnormalities on SS-OCTA and FA. Results: SS-OCTA showed decreased angiographic signal within the choriocapillaris in 5/6 eyes and corresponded to hypoperfusion abnormalities on FA in similar geographic distributions in 5/5 eyes. SS-OCTA also showed dilation of the deep retinal capillary plexus overlying the area of choroidal hypoperfusion in one eye. In the one eye without angiographic signal abnormalities on SS-OCTA, no perfusion changes were noted on FA. One control patient without ocular involvement from biopsy-confirmed GCA did not show choroidal perfusion changes on SS-OCTA or FA. Conclusions: This case series demonstrates comparability between SS-OCTA and FA in detection and characterization of choroidal hypoperfusion secondary to GCA. As a rapid and non-invasive tool, SS-OCTA may serve as a viable alternative to FA in the diagnostic evaluation of GCA.

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Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)

Cited by 140 publications

References 428 publications

Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

Microvasculature Features of Vogt-Koyanagi-Harada Disease Revealed by Widefield Swept-Source Optical Coherence Tomography Angiography

Detection of choroidal hypoperfusion in giant cell arteritis using swept-source optical coherence tomographic angiography

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