Seroprevalence of hepatitis c virus infection among blood donors in Ethiopia: a systematic review and meta-analysis

Lake, Eyasu Alem; Fite, Robera Olana; Gebrekirstos, Lielt Gebreselassie; Gebremedhin, Meron Hadis; Obsa, Mohammed Suleiman; Gelaw, Kelemu Abebe

doi:10.1186/s12879-021-05827-z

Cited by 3 publications

(1 citation statement)

References 40 publications

(23 reference statements)

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“…It was lower than 6.7% recently reported by Daramola et al (2020) [34] in the same facility in Ekiti, 3.6% reported by Okoroiwu et al (2018) [31] in Calabar and 6.0% reported by Buseri et al (2009) [3] in Osogbo respectively. However, it was higher than pooled seroprevalence of 0.8% reported by Lake et al (2021) [36] in a systematic and metaanalysis review among blood donors in Ethiopia and 0.39% reported by Macroo et al (2013) [37] in India. Anti-HCV seroprevalence of 0.5% have been reported by Erhabor et al (2006) [38] in Port-Harcourt.…”

Section: Discussioncontrasting

confidence: 54%

Sero-Epidemiology of Transfusion Transmissible Hepatitis B, C and E among Blood Donors in Ekiti, Southwestern Nigeria: A Cross-sectional Study

Fasakin

Muhibi

Ibijola

et al. 2022

JAMMR

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Background: Transfusion transmissible hepatitis (TTH) is a global health problem and the incriminating agents such as hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis E virus (HEV) continue to pose serious threats to blood safety. The aim of this study was to determine the seroprevalence of HBV, HCV and HEV and relate the outcomes with blood donation type, age and gender and confirm any significant associations. Materials and Methods: In this cross-sectional study, Hepatitis B surface antigen (HBsAg) and antibody to HCV were determined with Diaspot and Lab Acon immunochromatographic ELISA-based test devices. Antibodies to HEV were first determined with Biopanda lateral flow device followed by ELISA assay for sero-reactive HEV immunoglobulins M and immunoglobulin G (IgM and IgG) antibodies. Results: A total of 370 prospective blood donors between 18 and 55 years old (mean 31.2 ± 7.6 years) who presented for blood donation at FETHI Blood Bank were screened. Overall male: female ratio was 7:1. Cummulative hepatitis seroprevalence of 8.1% was found mainly among the replacement blood donors (RBD) and consist of 4.3%, 1.6%, 1.1%, 0.8% and 0.3% serologic evidence of HBsAg, anti-HCV, HEV IgM, both HEV IgM & HEV IgG, and HEV IgG antibodies. Blood donors aged 18 – 45 years were most affected with evident significant association between the age group of donors and TTH seroprevalence. Cummulative hepatitis seroprevalence was 0% among voluntary blood donors, and 9.1% and 0.3% among the male and female RBD respectively. There was significant association between the pathogens and RBD, though the association with male gender was clinically but not statistically significant. Conclusion: The high transfusion transmissible hepatitis seroprevalence among RBD called for promoting voluntary donations. Comparable prevalence of HEV antibodies with that of HCV called for its inclusion in the TTIs screening algorithm to ascertain optimal blood safety in Nigeria.

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Section: Discussioncontrasting

confidence: 54%

Sero-Epidemiology of Transfusion Transmissible Hepatitis B, C and E among Blood Donors in Ekiti, Southwestern Nigeria: A Cross-sectional Study

Fasakin

Muhibi

Ibijola

et al. 2022

JAMMR

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Hepatitis C virus seroprevalence, testing, and treatment capacity in public health facilities in Ghana, 2016–2021; A multi-centre cross-sectional study

Nartey,

Okine,

Seake-Kwawu

et al. 2023

PLoS ONE

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The current burden of Hepatitis C virus infection and the availability of HCV-related services in Ghana are not well described. Previous estimates on HCV seroprevalence in the country are outdated. This study investigated the HCV seroprevalence and testing and treatment capacity in Ghana. A multi-centre cross-sectional study was conducted in which laboratory and blood bank registers from 17 public healthcare institutions in Ghana were reviewed. A survey on cost and availability of HCV-related testing and treatment was also performed. Crude and pooled estimates of HCV seroprevalence, frequency and median cost of available diagnostic tests and medicines were described. The crude HCV seroprevalence was 2.62% (95% CI 2.53–2.72) and the pooled estimate was 4.58% (95% CI 4.06–5.11) among 103,609 persons tested in laboratories. Age (OR 1.02 95% CI 1.01–1.02) and male sex (OR 1.26 95% CI 1.08–1.48) were predictors of a positive anti-HCV RDT test. Northern administrative regions in Ghana had the highest HCV seroprevalence ranging from 8.3–14.4%. Among 55, 458 potential blood donors, crude HCV seroprevalence was 3.57% (95% CI 3.42–3.72). Testing was through Rapid Diagnostic Test (RDT) kits in most facilities, and only 2 of 17 centres were performing HCV RNA testing. The median cost of an anti-HCV RDT test was $0.97 (0–1.61) and $3.23 (1.61–7.58) for persons with and without government health insurance respectively. The median cost of a 12-week course of the pan-genotypic direct-acting antiviral therapy sofosbuvir-daclatasvir was $887.70. In conclusion, there are significant regional differences in HCV burden across Ghana. Limited access to and cost of HCV RNA and DAA therapy hinders testing and treatment capability, and consequently HCV elimination efforts. A national HCV program supported with a sustainable financing plan is required to accelerate HCV elimination in Ghana.

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Hepatitis B and hepatitis C virus infections and associated factors among prisoners in Gondar City, Northwest Ethiopia

Tadesse,

Ayalew,

Million

et al. 2024

PLoS ONE

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Background Globally, hepatitis B virus (HBV) and hepatitis C virus (HCV) cause considerable morbidity and mortality from their acute and chronic infections. The transmission of the viruses within the prisons is high due to overcrowding, and other risk behaviors such as drug use, and unsafe sexual practices. This study aimed at determining the prevalence and associated factors of HBV and HCV infections among prisoners in Gondar city, Northwest Ethiopia. Methods A cross-sectional study was conducted in the Gondar City Prison Center from May 1, 2022, to July 30, 2022. A total of 299 prison inmates were selected by using a systematic random sampling technique. A semi-structured questionnaire was used to collect data on sociodemographic, clinical, behavioral and prison related factors. Five milliliters of blood sample were collected, and the serum was separated from the whole blood. The serum was tested for HBV surface antigen (HBsAg) and anti-HCV antibody by using an Enzyme-Linked Immunosorbent Assay (ELISA). Data was entered using EpiData version 4.6.0 and exported to SPSS version 20 for analysis. Logistic regression analysis was done to assess the association between the independent variables and HBV and HCV infections. P-values < 0.05 were considered statistically significant. Results The overall seroprevalence of HBV or HCV infections was 10.4%. The seroprevalence of HBV and HCV infections was 7.0% and 4.0%, respectively. It has been demonstrated that having several heterosexual partners, sharing sharp materials in prison, having longer imprisonment, and having a body tattoo are significantly associated with HBV infection. The presence of a body tattoo, a history of surgical procedures, and previous imprisonment are associated risk factors for HCV infection. Conclusion The prevalence of HBV and HCV were high-intermediate and high, respectively. Therefore, preventative and control initiatives are needed in prisons to decrease the rate of infection and transmission.

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Seroprevalence of hepatitis c virus infection among blood donors in Ethiopia: a systematic review and meta-analysis

Cited by 3 publications

References 40 publications

Sero-Epidemiology of Transfusion Transmissible Hepatitis B, C and E among Blood Donors in Ekiti, Southwestern Nigeria: A Cross-sectional Study

Sero-Epidemiology of Transfusion Transmissible Hepatitis B, C and E among Blood Donors in Ekiti, Southwestern Nigeria: A Cross-sectional Study

Hepatitis C virus seroprevalence, testing, and treatment capacity in public health facilities in Ghana, 2016–2021; A multi-centre cross-sectional study

Hepatitis B and hepatitis C virus infections and associated factors among prisoners in Gondar City, Northwest Ethiopia

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