2021
DOI: 10.1017/s0950268821000236
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Abstract: This systematic review and meta-analysis aimed to evaluate thrombocytopenia as a prognostic biomarker in patients with coronavirus disease 2019 (COVID-19). We performed a systematic literature search using PubMed, Embase and EuropePMC. The main outcome was composite poor outcome, a composite of mortality, severity, need for intensive care unit care and invasive mechanical ventilation. There were 8963 patients from 23 studies. Thrombocytopenia occurred in 18% of the patients. Male gender (P = 0.037) significant… Show more

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Cited by 30 publications
(25 citation statements)
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“…(Martha et al, 2021;Pranata et al, 2020b;Wibowo et al, 2021aWibowo et al, , 2021b As cytokine storm is the underlying mechanism behind multisystem inflammatory process in severe COVID-19, the use of aspirin could theoretically a promising option in improving patients' outcomes and hindering the development of fatal complications, including ARDS, coagulopathy, sepsis, multi-organ dysfunction, and death. Pranata et al, 2021e) Aspirin has been found to reduce the generation of C-reactive protein (CRP), interleukin-6 (IL-6), and macrophage colony-stimulating factor, hence helps in mitigating cytokine storm as well as exerting cardio-respiratory protective actions. (Mehta et al, 2020) Moreover, ASA had markedly lower initial plasma fibrinogen level through fibrinogen acetylation and fibrinolysis acceleration, therefore decreasing the risk of thrombotic and bleeding events.…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
“…(Martha et al, 2021;Pranata et al, 2020b;Wibowo et al, 2021aWibowo et al, , 2021b As cytokine storm is the underlying mechanism behind multisystem inflammatory process in severe COVID-19, the use of aspirin could theoretically a promising option in improving patients' outcomes and hindering the development of fatal complications, including ARDS, coagulopathy, sepsis, multi-organ dysfunction, and death. Pranata et al, 2021e) Aspirin has been found to reduce the generation of C-reactive protein (CRP), interleukin-6 (IL-6), and macrophage colony-stimulating factor, hence helps in mitigating cytokine storm as well as exerting cardio-respiratory protective actions. (Mehta et al, 2020) Moreover, ASA had markedly lower initial plasma fibrinogen level through fibrinogen acetylation and fibrinolysis acceleration, therefore decreasing the risk of thrombotic and bleeding events.…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
“…Raymond systematically reviewed 23 studies with a total of 8963 COVID-19 patients, the incidence of thrombocytopenia was 18%, the incidence of sequelae in patients with thrombocytopenia was 50%, and the incidence of sequelae in patients without thrombocytopenia is 26%. 61 Yang also retrospectively analyzed the platelet counts of 1476 COVID-19 patients and found that 306 (20.7%) had thrombocytopenia, and 238 (16.1%) were died, and the mortality rate was related to the degree of thrombocytopenia, it means the lower the count platelet is, the higher mortality rate . 62 In this study, the mortality rate of platelet counts between (0–50) ×10 9 /L was 92.1%, while that of platelet count greater than 150×10 9 /L was only 4.7%.…”
Section: Covid-19 and Plateletsmentioning
confidence: 99%
“…Although initially used as a marker of liver fibrosis, FIB-4 index has been repurposed for prognostication in patients with COVID-19, with or without liver disease [ 7 , 9 11 ]. Age, liver injury, and thrombocytopenia have been shown to increase mortality in COVID-19 [ 1 , 5 , 6 , 12 ]. However, in Table 1 , only platelets is significantly lower in patients with COVID-19.…”
Section: Resultsmentioning
confidence: 99%
“…Liver enzymes and platelets are often altered in patients with hematological malignancies; and might be useful for predicting outcome. Thrombocytopenia in also often encountered in patients with COVID-19 and signifies poor prognosis [ 5 ].…”
Section: Introductionmentioning
confidence: 99%