“…(Martha et al, 2021;Pranata et al, 2020b;Wibowo et al, 2021aWibowo et al, , 2021b As cytokine storm is the underlying mechanism behind multisystem inflammatory process in severe COVID-19, the use of aspirin could theoretically a promising option in improving patients' outcomes and hindering the development of fatal complications, including ARDS, coagulopathy, sepsis, multi-organ dysfunction, and death. Pranata et al, 2021e) Aspirin has been found to reduce the generation of C-reactive protein (CRP), interleukin-6 (IL-6), and macrophage colony-stimulating factor, hence helps in mitigating cytokine storm as well as exerting cardio-respiratory protective actions. (Mehta et al, 2020) Moreover, ASA had markedly lower initial plasma fibrinogen level through fibrinogen acetylation and fibrinolysis acceleration, therefore decreasing the risk of thrombotic and bleeding events.…”