Blood group A epitopes do not facilitate entry of SARS‐CoV‐2

Schetelig, Johannes; Baldauf, Henning; Wendler, Sarah; Heidenreich, Falk; Real, Ruben; Kolditz, Martin; Rosner, Andrea; Dalpke, Alexander H.; With, Katja de; Lange, Vinzenz; Markert, Jan; Barth, Ralf; Bunzel, Carolin; Endert, Dennis; Hofmann, Jan A.; Sauter, Jürgen; Bernas, Stefanie N.; Schmidt, Alexander H.

doi:10.1111/joim.13256

Cited by 9 publications

(12 citation statements)

References 10 publications

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“…Therefore, we decided not to analyze the risk of contracting SARS-CoV-2 by HLA genotype. Details on the data collection, demographic information of SARS-CoV-2 positive and negative participants and results of the analysis of clinical risk factors and ABO blood groups have been published previously (33,34).…”

Section: Medical Datamentioning

confidence: 99%

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

et al. 2021

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HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype.

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Section: Medical Datamentioning

confidence: 99%

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

et al. 2021

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“…Of 314 potentially relevant reports identified after eliminating duplicates, supplemented with one paper of the authors accepted for publication, 23 of them met the inclusion criteria. Five of the 23 included studies were CCS [ 18 , 22 , 23 , 24 , 25 ], and the remaining 18 were CS or cross-sectional studies [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ] as reported by the authors of the papers or deduced from the authors of this review.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies were published in 2020 [ 22 , 27 , 28 , 34 , 35 , 39 ] and 17 studies in 2021 [ 18 , 23 , 24 , 25 , 26 , 29 , 30 , 31 , 32 , 33 , 36 , 37 , 38 , 40 , 41 , 42 , 43 ]. All included studies were carried out in the pre-vaccinal period: between February and July 2020 for studies published in 2020, and until November 2020 for those published in 2021.…”

Section: Resultsmentioning

confidence: 99%

“…All included studies were carried out in the pre-vaccinal period: between February and July 2020 for studies published in 2020, and until November 2020 for those published in 2021. Eleven of the 23 studies were carried out in Europe [ 18 , 24 , 26 , 27 , 28 , 29 , 34 , 36 , 40 , 42 , 43 ], of which five were in the United Kingdom [ 24 , 26 , 34 , 36 , 43 ], nine studies in America [ 23 , 25 , 30 , 31 , 32 , 35 , 37 , 39 , 41 ], of which seven were in the USA [ 23 , 25 , 30 , 31 , 32 , 35 , 39 ], and only three in Asia (Saudi Arabia, Iraq and Iran) [ 22 , 33 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“… Forest plot for the occurrence of SARS-CoV-2 infection in patients with Blood Group AB versus non-AB [ 18 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. …”

Section: Figurementioning

confidence: 99%

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The Role of ABO Blood Type in Patients with SARS-CoV-2 Infection: A Systematic Review

Banchelli

Negro

Guido

et al. 2022

JCM

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The SARS-CoV-2 infection has caused over 422 million contagions and 5.8 million deaths resulting in a global health crisis. Several studies have investigated the risk factors predisposing to the infection and reported that the host susceptibility can be linked to the ABO blood group, but the current evidence is controversial. We systematically searched for articles in EMBASE, PubMed, and Cochrane library published up to 7 May 2021 to explore the association of the ABO blood group with the susceptibility to SARS-CoV-2 infection. All studies in people undergoing SARS-CoV-2 test controls were included. Odds ratios were obtained in each study and then synthesised by using meta-analysis. Overall, 22 articles were selected and more than 1,200,000 individuals of whom 74,563 resulted positive to SARS-CoV-2 and 1,166,717 resulted negative, were included in the meta-analysis. Overall, 487,985 subjects had blood group A, 151,879 had group B, 52,621 had group AB, and 548,795 had group O. Group O was slightly less associated with infection, as compared to the other three blood groups (OR = 0.91, 95% CI = 0.85–0.99, p = 0.02). Conversely, group A was slightly more associated with infection, as compared to the other three groups (OR = 1.06, 95% CI = 1.00–1.13, p = 0.04). This meta-analysis shows associations between blood groups and SARS-CoV-2 infection and supports the hypothesis that blood type O may have a slightly lower risk of infection, whereas blood type A may have a slightly higher risk of infection.

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Association between ABO blood group/genotype and COVID-19 in a Japanese population

et al. 2023

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Blood group A epitopes do not facilitate entry of SARS‐CoV‐2

Abstract: The risk of contracting SARS-CoV-2 was slightly higher for individuals with blood group A versus O but did not differ between blood groups A 1 versus A 2 . With much higher epitope density of blood group A 1 , this suggests that the A epitope itself does not facilitate viral entry.

Cited by 9 publications

References 10 publications

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

The Role of ABO Blood Type in Patients with SARS-CoV-2 Infection: A Systematic Review

Association between ABO blood group/genotype and COVID-19 in a Japanese population

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