Balanced crystalloids versus saline in critically ill adults with low plasma bicarbonate: A secondary analysis of a clinical trial

Order Substitutions and Education for Balanced Crystalloid Solution Use in an Integrated Health Care System and Association With Major Adverse Kidney Events

“…Among patients who received higher volume infusions (>3000 mL) during their hospitalization, we observed a trend toward lower relative MAKE30 events compared with patients who received smaller volume infusions (eFigure 8 in the Supplement). Medical inpatients and ED patients not admitted to the hospital appeared to derive greater benefits than surgery patients, similar to other prior studies . Inclusion of a high proportion of elective surgical patients in the SPLIT and BaSICS trials may have contributed to their negative findings …”

“…Medical inpatients and ED patients not admitted to the hospital appeared to derive greater benefits than surgery patients, similar to other prior studies. 14 , 26 , 27 , 28 , 29 Inclusion of a high proportion of elective surgical patients in the SPLIT and BaSICS trials 13 , 14 may have contributed to their negative findings. 30 …”

“…Education for Balanced Crystalloid Solution Use and Association With Major Adverse Kidney Events similar to other prior studies. 14,[26][27][28][29] Inclusion of a high proportion of elective surgical patients in the SPLIT and BaSICS trials 13,14 may have contributed to their negative findings. 30 Intervention timing in our study, as with previous trials, appeared to be critical for patient level benefit.…”