2021
DOI: 10.1002/alz.12281
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Abstract: Introduction Individuals in early dementia prevention trials may differ in how much they benefit from interventions depending on their initial risk level. Additionally, modifiable dementia risk scores might be used as surrogate/intermediate outcomes. Methods In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated in post hoc analyses (N = 1207) whether the cognitive benefits of the 2‐year multi‐domain lifestyle intervention differed by baseline demen… Show more

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Cited by 24 publications
(24 citation statements)
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“…Furthermore, we focused on both detrimental and beneficial lifestyle changes. Additionally, to estimate the future risk of cognitive decline we used the LIBRA score, which is a well-validated measurement for predicting cognitive decline and higher dementia risk in various general population and patient-studies ( 42 ). Further, LIBRA focuses solely on modifiable risk factors, making participants with higher LIBRA scores especially susceptible for lifestyle changes and altering their future cognitive decline.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, we focused on both detrimental and beneficial lifestyle changes. Additionally, to estimate the future risk of cognitive decline we used the LIBRA score, which is a well-validated measurement for predicting cognitive decline and higher dementia risk in various general population and patient-studies ( 42 ). Further, LIBRA focuses solely on modifiable risk factors, making participants with higher LIBRA scores especially susceptible for lifestyle changes and altering their future cognitive decline.…”
Section: Discussionmentioning
confidence: 99%
“…We selected 12 AD‐related traits reflecting different aspects of AD etiology, based on literature review 10 and the availability of GWAS summary statistics. These traits include comorbidities (total cholesterol [TC], 11 type 2 diabetes [T2D], 12 blood pressure, 13 body mass index [BMI], 14 and inflammation [C‐reactive protein (CRP)] 15 ), psychosocial factors (educational attainment [EA], 16 premorbid intelligence [INT], 17 premorbid cognitive performance [COG], 18 and overall subjective well‐being [SWB] 19 ), and neuroimaging features (hippocampal volume, susceptibility‐weighted T1 imaging [SWI] linked to age‐related iron deposition in the brain; Table S1).…”
Section: Methodsmentioning
confidence: 99%
“…We selected 12 AD-related traits reflecting different aspects of AD etiology, based on literature review 10 S1).…”
Section: Ad-related Traitsmentioning
confidence: 99%
“…Het is een onderwerp waarmee ons Alzheimer Centrum zich de laatste jaren steeds meer bezig heeft gehouden. Samen met een internationale onderzoeksgroep hebben wij een vragenlijst ontwikkeld, de Lifestyle Index for Brain Health, ofwel LIBRA, waarmee je je eigen individueel risicoprofiel kunt monitoren (19,20). Onder leiding van (bijna-) professor Sebastian Koehler en samen met collega's Martin van Boxtel en Kay Deckers is hiermee afgelopen jaren veel onderzoek gedaan.…”
Section: Levensloop Model En Preventieunclassified