Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients

Nakagawa, So; Kawashima, Mitsuo; Miyatake, Yuji; Kudo, Kai; Kotaki, Ryutaro; Ando, Kiyoshi; Kotani, Ai

doi:10.1016/j.gene.2020.145363

Cited by 7 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have demonstrated a potential implication of ERVs in a wide spectrum of human malignancies including hematologic malignancies and solid tumors. High expression levels of the Env protein of ERV-3-1 were found in all patients with Acute myeloid leukemia (AML) included in one cohort while this effect was more specific for bone marrow and blood cells and was closely associated with a myeloid phenotype of AML in this study (208). Concerning hematologic malignancies, Myelodysplastic syndrome (MDS) is a heterogeneous category of hematological diseases that are recognized predisposition factors for the development of myeloid lineage malignancies, most commonly myeloid leukemia (209).…”

Section: Hervs and Human Cancer: Link Therapeutic And Prognostic Perspectivesmentioning

confidence: 48%

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

et al. 2021

View full text Add to dashboard Cite

Being responsible for almost 12% of cancers worldwide, viruses are among the oldest known and most prevalent oncogenic agents. The quality of the evidence for the in vivo tumorigenic potential of microorganisms varies, thus accordingly, viruses were classified in 4 evidence-based categories by the International Agency for Research on Cancer in 2009. Since then, our understanding of the role of viruses in cancer has significantly improved, firstly due to the emergence of high throughput sequencing technologies that allowed the “brute-force” recovery of unknown viral genomes. At the same time, multi-omics approaches unravelled novel virus-host interactions in stem-cell biology. We now know that viral elements, either exogenous or endogenous, have multiple sometimes conflicting roles in human pathophysiology and the development of cancer. Here we integrate emerging evidence on viral causality in human cancer from basic mechanisms to clinical studies. We analyze viral tumorigenesis under the scope of deep-in-time human-virus evolutionary relationships and critically comment on the evidence through the eyes of clinical epidemiology, firstly by reviewing recognized oncoviruses and their mechanisms of inducing tumorigenesis, and then by examining the potential role of integrated viruses in our genome in the process of carcinogenesis.

show abstract

Section: Hervs and Human Cancer: Link Therapeutic And Prognostic Perspectivesmentioning

confidence: 48%

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“… 81 More importantly, the presence of the ERV‐3‐1 protein was confirmed on the surface of leukemic cells of all myeloid‐phenotype AML patients and the majority of monocytic‐phenotype patients in immunohistochemical studies. 81 ERV‐3‐1 upregulated expression was correlated to chromosome 8 trisomy leukemic genotype, however, this correlation was not significant in the immunohistochemical study for the identification of the ERV‐3‐1 protein on leukemic cells. 81 Deregulated HERV expression patterns are recognized in multiple AML differentiation types.…”

Section: Herv Participation In Malignancies and Clinical Implicationsmentioning

confidence: 87%

Section: Herv Participation In Malignancies and Clinical Implicationsmentioning

confidence: 90%

“…Additionally, the expression of ERV‐3‐1 is upregulated in the blood and bone marrow cells of patients with AML, and this upregulation was more prominent in the myeloid lineage compared to the monocytic one 81 . More importantly, the presence of the ERV‐3‐1 protein was confirmed on the surface of leukemic cells of all myeloid‐phenotype AML patients and the majority of monocytic‐phenotype patients in immunohistochemical studies 81 . ERV‐3‐1 upregulated expression was correlated to chromosome 8 trisomy leukemic genotype, however, this correlation was not significant in the immunohistochemical study for the identification of the ERV‐3‐1 protein on leukemic cells 81 .…”

Section: Herv Participation In Malignancies and Clinical Implicationsmentioning

confidence: 99%

See 1 more Smart Citation

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

Kitsou

Λάγιου

Magiorkinis

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have been co‐opted in human physiological functions while their aberrant expression is linked to human disease. The role of HERVs in multiple malignancies has been demonstrated, however, the extent to which HERV activation and expression participate in the development of cancer is not yet fully comprehended. In this review article, we discuss the presumed role of HERVs in carcinogenesis and their promising diagnostic and prognostic implications. Additionally, we explore recent data on the HERVs in cancer therapeutics, either through the manipulation of their expression, to induce antitumor innate immunity responses or as cancer immunotherapy targets. Finally, more precise and higher resolution high‐throughput sequencing approaches will further elucidate HERV participation in human physiological and pathological processes.

show abstract

“…Human ERV-K (HERV-K) is actively expressed in human melanoma, and their protein expression, as well as particle formation, have been reported (3,4). ERV3-1, an env gene of HERV-R, is also reported to be expressed in colorectal cancers (5) and acute myelogenous leukemia (6). In mice, active expression of an ERV called MelARV has been reported in B16/BL6 melanoma cells (7,8).…”

Section: Introductionmentioning

confidence: 99%

Systematic Identification of Endogenous Retroviral Protein-Coding Genes Expressed in Canine Oral Malignant Melanoma

et al. 2021

Self Cite

View full text Add to dashboard Cite

Endogenous retroviruses (ERVs) are remnants of ancestral retroviruses that infected host germ cells in the past. Most ERVs are thought to be non-functional elements, but some ERVs retain open reading frames (ORFs) capable of expressing proteins. The proteins encoded by ERV-ORFs have potential roles in oncogenesis; however, studies on mammals other than humans and mice are limited. Here, we identified ERV-derived genes expressed in canine oral malignant melanoma (OMM). We identified 11 ERV-derived genes in our OMM samples. Differential expression gene analysis revealed that four ERV-derived genes (PEG10, LOC102155597, and two newly identified genes) were upregulated in OMM compared to healthy tissues. PEG10 is a conserved long terminal repeat (LTR)-type retrotransposon-derived gene among mammals and is involved in human cancers. LOC102155597 is a retroviral env gene conserved in Carnivora. This Env protein harbors an immunosuppressive domain, implying the potential adverse effects on the immune system. While the production of viral particles from ERVs has been reported in human and mouse melanoma, we found no ERV-derived genes having the potential to produce viral particles. These results provide insights into the different and conserved features of ERV-derived genes in mammalian melanoma.

show abstract

Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients

Cited by 7 publications

References 36 publications

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

Systematic Identification of Endogenous Retroviral Protein-Coding Genes Expressed in Canine Oral Malignant Melanoma

Contact Info

Product

Resources

About