2021
DOI: 10.1016/j.cdtm.2020.11.002
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Abstract: A significant number of SARS‐CoV‐2 (COVID‐19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mito… Show more

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Cited by 68 publications
(64 citation statements)
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References 117 publications
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“…The “long haulers” with ME/CFS, who do not make a straight-forward recovery in the post-viral period, probably reflect damage by the host response to the initial infection [ 126 ]. A severe host response (e.g., the “cytokine storm”), indeed, can give rise to oxidative and inflammatory damage and generalized oxidative stress.…”
Section: Resultsmentioning
confidence: 99%
“…The “long haulers” with ME/CFS, who do not make a straight-forward recovery in the post-viral period, probably reflect damage by the host response to the initial infection [ 126 ]. A severe host response (e.g., the “cytokine storm”), indeed, can give rise to oxidative and inflammatory damage and generalized oxidative stress.…”
Section: Resultsmentioning
confidence: 99%
“…Some of the long-term symptoms may also be related to invasive treatments used and lasting pathologies at tissue sites other than the lung 65,69 and mitochondrial pathways. 71 As our knowledge in long COVID-19 cases continues to emerge, it is likely that the care of such patients entails a multidisciplinary approach.…”
Section: Clinical Characteristicsmentioning
confidence: 99%
“…While the underlying mechanisms for these long‐term effects still remain incompletely understood, persistent lung injuries have been seen in COVID‐19‐recovered patients (detailed in Section 4 below). Some of the long‐term symptoms may also be related to invasive treatments used and lasting pathologies at tissue sites other than the lung 65,69 and mitochondrial pathways 71 . As our knowledge in long COVID‐19 cases continues to emerge, it is likely that the care of such patients entails a multidisciplinary approach.…”
Section: Clinical Featuresmentioning
confidence: 99%
“…An example is chronic fatigue syndrome, currently known as myalgic encephalomyelitis. An understanding of COVID-19 might provide insights into this condition and the reverse may be true as well [9,10].…”
Section: Operational Foundationmentioning
confidence: 99%