Autologous fat grafting seems to alleviate postherpetic neuralgia – a feasibility study investigating patient-reported levels of pain

Sollie, Martin; Thomsen, Jørn Bo; Sørensen, Jens Ahm

doi:10.1016/j.bjps.2020.08.038

Cited by 7 publications

(11 citation statements)

References 33 publications

(34 reference statements)

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“…Previously, Sollie et al. ( 2020 ) first launched a clinical trial and proven that autologous fat grafting is a safe and feasible technique in alleviating neuropathic pain resulting from PHN, and the grafting area they choose is the dermal area with chronic pain. According to their theory, by grafting the fat to the affected skin could reduce neuroinflammation and restore the skin innervation.…”

Section: Discussionmentioning

confidence: 99%

“…Sollie et al. ( 2020 ) first reported a potential benefice of autologous fat grafting to the dermal area in alleviating PHN. Based on comprehensive analysis of the pathogenesis of PHN and related studies, we hypothesized that autologous fat injection around spinal nerve roots may have a preventive effect for chest‐back PHN.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism for this therapy to reduce chronic pain is uncertain, animal studies infer that adipokines and mesenchymal stem cells in the adipose tissue may have an anti-inflammatory effect. Sollie et al (2020) first reported a potential benefice of autologous fat grafting to the dermal area in alleviating PHN. Based on comprehensive analysis of the pathogenesis of PHN and related studies, we hypothesized that autologous fat injection around spinal nerve roots may have a preventive effect for chest-back PHN.…”

Section: Introductionmentioning

confidence: 99%

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Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia—A single‐arm pilot study

Tao

Meng

et al. 2023

Brain and Behavior

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Introduction Postherpetic neuralgia (PHN) is one of the most common complications of Herpes zoster (HZ), yet the mechanism and the treatment for PHN remains elusive. We first performed this feasibility study to verify the safety and efficiency of autologous fat grafting into the paravertebral space in early HZ to prevent PHN. Methods Patients suffering from HZ with a rash in chest, back, or abdomen were arranged for autologous fat grafting to the paravertebral space. The primary endpoint was the incidence of PHN, which was defined as persistence pain in the affected dermal area in 12 weeks after fat grafting. Secondary endpoints including patient‐reported changes in pain intensity, assessed pain threshold and the quality of life during follow‐ups. Results Eight patients accept the intervention and completed all follow‐ups. Most patients report immediate pain relief after injection, one patient has a mild to moderate dizzy symptom after injection. No other short‐ or long‐term adverse events occurred. For primary outcome, all patients have a timely reduced pain intensity, with no PHN events occurred, as all patients report pain intensity ≤3 in the VAS scale in 3 months after treatment. For electrical pain threshold, we identify that fat grafting differentially increases sensation and pain threshold in HZ area and healthy skin of patients. Besides, our results indicate significant improvement in patients’ life quality decrease in analgesic consumption. Discussion Autologous fat transplantation to the paravertebral space is a safe and feasible technique in preventing PHN from HZ in a rash. Further randomized controlled trial to investigate the actual long‐term benefice of autologous fat grafting to the paravertebral space in preventing PHN is needed. Trial registration ChiCTR, (ChiCTR1900025416); registered August 26, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia—A single‐arm pilot study

Tao

Meng

et al. 2023

Brain and Behavior

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“…NCT04560361 was conducted by Nanjing University of Chinese Medicine to explore the effect of EA on PHN ( Another trial NCT03584061 is a pilot study to investigate autologous fat grafting on chronic PHN (Table 2, Line 13). A clinical observation study reported that autologous fat grafting might relieve chronic pain resulting from HZ (Sollie et al, 2021).…”

Section: Potential Physical Meansmentioning

confidence: 99%

Potential novel therapeutic strategies for neuropathic pain

Zhang

Han

et al. 2023

Front. Mol. Neurosci.

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PurposeTo explore the potential therapeutic strategies of different types of neuropathic pain (NP) and to summarize the cutting-edge novel approaches for NP treatment based on the clinical trials registered on ClinicalTrials.gov.MethodsThe relevant clinical trials were searched using ClinicalTrials.gov Dec 08, 2022. NP is defined as a painful condition caused by neurological lesions or diseases. All data were obtained and reviewed by the investigators to confirm whether they were related to the current topic.ResultsA total of 914 trials were included in this study. They were divided into painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), sciatica (SC), peripheral nerve injury-related NP (PNI), trigeminal neuralgia (TN), chemotherapy-induced NP (CINP), general peripheral NP (GPNP) and spinal cord injury NP (SCI-NP). Potential novel therapeutic strategies, such as novel drug targets and physical means, were discussed for each type of NP.ConclusionNP treatment is mainly dominated by drug therapy, and physical means have become increasingly popular. It is worth noting that novel drug targets, new implications of conventional medicine, and novel physical means can serve as promising strategies for the treatment of NP. However, more attention needs to be paid to the challenges of translating research findings into clinical practice.

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“…All articles spoke to the effectiveness of this technique. [13][14][15][16][17] Although this is a mix of lower-and medium-level evidence, it does suggest that more research is needed to fully determine the usefulness of AFG in painful neuromas. The suggested most likely mechanism for reduction of pain includes fat acting as a protective barrier around the sensitive nerve endings.…”

Section: Painful End Neuromas and Other Neuropathic Painmentioning

confidence: 99%

Autologous Fat Grafting: Evaluation of Efficacy in Pain Relief

Klomparens

Simman

2022

Plastic and Reconstructive Surgery - Global Open

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Introduction: Autologous fat grafting (AFG) has been used in reconstructive plastic surgery for over a century. Although it has obvious benefits to the aesthetic appearance of many reconstructive surgeries, less appreciated advantages of fat grafting have also been shown in potential pain reduction. This can be seen across the board from head to toe with examples ranging from facial nerve injury to pedal atrophy and foot ulcers. The purpose of this literature review is to evaluate the efficacy of AFG for pain relief in various indications and serve as a reference for clinicians to gain insight on potentially beneficial therapies for their patients. Methods: A broad literature review was performed to analyze the various uses of AFG for pain management by various indications including postmastectomy pain syndrome, scar pain, neuromas, chronic wounds and many more. The PubMed, Science Direct and Scopus online databases were searched using keywords such as “autologous fat grafting,” “reconstruction,” “pain,” and “therapy.” Results: At this point, there is decent evidence to support AFG’s role in pain resolution in postmastectomy pain syndrome, neuropathic scar pain, and pedal injury. There is also ample low-level evidence for pain efficacy in autoimmune diseases, neuromas, vulvar lichen sclerosis, burns, and radiation-induced wounds. Conclusions: While there is a clear lack of higher-level evidence based studies conducted on AFG for all indications, the existing literature shows a definite trend of reconstructive efficacy and pain management that can be clearly appreciated. With the increasing popularity of this procedure for reconstruction, higher-level studies are beginning to take place pertaining to AFG’s efficacy not only in reconstruction, but pain management as well.

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Autologous fat grafting seems to alleviate postherpetic neuralgia – a feasibility study investigating patient-reported levels of pain

Cited by 7 publications

References 33 publications

Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia—A single‐arm pilot study

Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia—A single‐arm pilot study

Potential novel therapeutic strategies for neuropathic pain

Autologous Fat Grafting: Evaluation of Efficacy in Pain Relief

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