32 Results of Dietary and Environmental Measures for the Prevention of Atopy in at-Risk Babies: Follow-Up to 3 Years 8 Months of Age

Abstract

Miinchen.Today, it is possible to identify the majority of the newborns with a high risk of atopy by recording family history (FH) and determination of cord-blood IgE (CB-IgE). But this selective screening cannot detect the total number of newborns at risk of atopy. The aim of the present study was to investigate the value of T-cell suppressor count in newborns for the prediction of atopy. We studied CB-IgE, T-cell counts and FH in 138 non-selected newborns. No measures were undertaken for the prevention of atopy. A control determination of IgE and T-cell function was performed at 14 months age.All children with elevated CH-IgE and low T-Suppressor cell count in the cord blood (11%) developed clinical signs of atopy.The risk of atopy was significantly higher in children with low CB-T-suppressor cell count and pOSe FH compared to normal controls (p 0,01). High CB-IgE or low T-suppressor cell count are of similar value for the prediction of atopy. At the age of 14 months, no correlation could be drawn between 19E, T-suppressor cell count and atopy symptoms. The 20 kD component present in birch pollen seems to be responsible for the crossreactivity with fruits, whereas the 18 kD component of bir'ch pollen seems to be responsible for the crossreactivity with grass pollen, potato and fruits. The crossreacting determinant on the 14 kD component is present in pollens (e.g. grass pollen) and other vegetable materials (e.g. potato). Support from the Welcome Trust is gratefully acknOWledged. No srroking in the house, strict controls for the elimination of house duSt,Irolds and mites, no pets in the house, day-care attendance delayed to after 3 yrs. All the infants were seen at our Clinic at the age of 1,3,6,9,12 nos and twice-a-year aft.e:l:wards. The median age of the 244 children at the last follow up was 3yrs+8Iros(Range 7 nos-8 yrs). 26 (14,5%) of the 179 breasl>-or soy-fed and 25 (38,5%) of 65 CM-fed infants developed atopic diseases during the follow-up (p< 0,001). In detail, 8 of the 26 breast-or soy-fed infants showed atopic dermatitis (AD} ,14 ast!nla, 1 rhinitis, 2 asthna associated with AD, and 1 urticaria.2 of the 25 CM-fed infants showed AD, 13 asthma, 2 rhinitis, and 8 astlma associated with AD. These data suggest that dietary and environmental measures exert a prophylactic effect on the developnent of atopic diseases in at-risk iiifants. 35 AEROSOL CHALLENGE ALTERS THE PERMEABILITY OF THE TRACHEA IN SENSITIZED RATSAllergic disease is very common in children. The disease is characterized by a variety of symptoms. When a child is referred to the pediatrician, the allergy has caused many problems. The sensitization to the different allergens has already taken place.The avoidance of allergens results in a decrease of symptoms.Since five year we follow-up the development of specific IgE for food and inhaled allergens in patients with a family history of atopy. In a group of young children we could demonstrate that the development of specific IgE for inhaled allergens was preceeded by specific IgE for food aller...

Prevention of childhood allergy by dietary manipulation

“…The results of our studies show that the onset of allergic disease is significantly reduced using the prevention measures. Summing up our studies using a soy-protein formula when breast-milk was not available, we did not see an increased prevalence of soy sensitization [13][14][15][16]. However, other studies failed to show any preventive effect of soy formulae [17,18].…”

Natural history of atopic dermatitis in childhood: an updated review and personal experience of a five-year follow-up

“…Several studies have emphasized the relationship between CM formula feeding and development of atopic dermatitis (20)(21)(22)(23). The prospective study by Queille-Roussel et al (3) showed that CM formula feeding was an unfavorable fac- tor for the development of AD.…”

In 2532 Children we Report the Developmental Factors Influencing the Development of Atopic Diseases

“…Some studies have shown that soy formulas or breast-feeding supplemented with soy formula for the first six months of life significantly reduce the prevalence of atopic diseases [56][57]. In our studies, using a soy protein formula when breast-milk was not available, we did not see an increased prevalence of soy sensitization [6,7,48,58].However, other studies failed to show any preventive effect of soy formulas [59,60]. These contradictory results may be explained by different factors.…”