Abstract:Psoriasis is generally thought to has the aspects of a genetic predisposition and environmental insults. Around one-third of patients report a family history and identical twin studies suggest a 70% chance of onset if the other twin has psoriasis. The prevalence rate in the Western countries is 2 to 3%, however, it's only 0.2 % in Japan. The aldo-keto reductase (AKR) 1C3, a NAD(P)H-dependent oxidoreductase, is reported to induce keratin 10 and reduce loricrin in the human skin. Down-regulation of AKR1C3 induce… Show more
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